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Parvovirus B19 Infection Studies
Research Guide
What is Parvovirus B19 Infection Studies?
Parvovirus B19 Infection Studies is a research field examining the infection mechanisms, pathogenesis, and clinical consequences of Parvovirus B19, with emphasis on fetal hydrops, autoimmune diseases, pregnancy complications, viral transmission, and associations with hematological and rheumatic disorders in immunocompetent and immunocompromised hosts.
The field encompasses 38,268 published works on Parvovirus B19, focusing on its role in intrauterine infections and nonimmune hydrops fetalis. Studies address viral persistence and transmission pathways in diverse patient populations. Growth rate over the past five years is not available from the data.
Topic Hierarchy
Research Sub-Topics
Parvovirus B19 Pathogenesis
Studies elucidate viral replication cycles, host cell tropism focusing on erythroid progenitors, and molecular mechanisms of cytotoxicity. Research examines VP1 unique region phospholipase activity and cellular signaling disruption.
Parvovirus B19 in Pregnancy and Fetal Hydrops
Investigates transplacental transmission, fetal infection outcomes, and nonimmune hydrops fetalis etiology. Longitudinal studies assess intrauterine transmission rates and fetal monitoring protocols.
Parvovirus B19 and Autoimmune Diseases
Research explores molecular mimicry, persistent infection, and triggering of rheumatoid arthritis, systemic lupus erythematosus, and antiphospholipid syndrome. Epidemiological and immunological association studies predominate.
Parvovirus B19 in Immunocompromised Hosts
Focuses on chronic infection, pure red cell aplasia, and treatment responses with IVIG in transplant recipients and HIV patients. Viral persistence mechanisms and genotyping correlations are studied.
Parvovirus B19 Transmission and Epidemiology
Epidemiological studies track seroprevalence, outbreak patterns, respiratory droplet transmission, and blood product safety measures. Genotype distribution and molecular epidemiology are key areas.
Why It Matters
Parvovirus B19 infection studies inform clinical management of pregnancy complications, including fetal hydrops, by detailing viral effects on erythroid cells and fetal development. Ahmad Almilaji et al. (2013) showed that human Parvovirus B19 capsid protein VP1 down-regulates Na+/K+-ATPase activity, revealing molecular mechanisms underlying anemia and hydrops fetalis, with the paper garnering 8696 citations. These findings aid diagnosis and treatment in immunocompromised hosts and link the virus to autoimmune and rheumatic disorders, guiding interventions in hematology and obstetrics.
Reading Guide
Where to Start
'Down-Regulation of Na+/K+-ATPase Activity by Human Parvovirus B19 Capsid Protein VP1' by Ahmad Almilaji et al. (2013), as it provides a specific, highly cited (8696 times) molecular mechanism central to Parvovirus B19 pathogenesis, offering a concrete entry into cellular effects.
Key Papers Explained
Ahmad Almilaji et al.'s (2013) 'Down-Regulation of Na+/K+/K+-ATPase Activity by Human Parvovirus B19 Capsid Protein VP1' establishes VP1's direct cellular impact (8696 citations). Peter Pushko et al.'s (2013) 'Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures' extends this to vaccine applications using parvovirus-derived VLPs (5967 citations). Jan-Inge Henter et al.'s (2006) 'HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis' connects to potential parvovirus-triggered hematological crises (5116 citations), building a progression from mechanism to diagnostics.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Field description indicates ongoing focus on pathogenesis in fetal hydrops and immunocompromised hosts, with no recent preprints or news available. Research continues on viral transmission and autoimmune links, as reflected in the 38,268 works.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Down-Regulation of Na<sup>+</sup>/K<sup>+</sup>ATPase Activity... | 2013 | Cellular Physiology an... | 8.7K | ✓ |
| 2 | Development of Virus-Like Particle Technology from Small Highl... | 2013 | Intervirology | 6.0K | ✓ |
| 3 | HLH‐2004: Diagnostic and therapeutic guidelines for hemophagoc... | 2006 | Pediatric Blood & Cancer | 5.1K | ✕ |
| 4 | Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in ... | 1995 | New England Journal of... | 2.9K | ✓ |
| 5 | Natural History of Cervicovaginal Papillomavirus Infection in ... | 1998 | New England Journal of... | 2.3K | ✓ |
| 6 | Epstein-Barr virus. | 2002 | PubMed | 2.2K | ✕ |
| 7 | Epstein–Barr virus: 40 years on | 2004 | Nature reviews. Cancer | 2.2K | ✕ |
| 8 | A newly discovered human pneumovirus isolated from young child... | 2001 | Nature Medicine | 2.1K | ✓ |
| 9 | New Delhi, India | 2014 | — | 1.9K | ✕ |
| 10 | NATURAL HISTORY OF CERVICOVAGINAL PAPILLOMAVIRUS INFECTION IN ... | 1998 | — | 1.9K | ✕ |
Frequently Asked Questions
What molecular mechanism does Parvovirus B19 use to affect host cells?
Human Parvovirus B19 capsid protein VP1 down-regulates Na+/K+-ATPase activity in host cells. Ahmad Almilaji et al. (2013) demonstrated this effect in their study 'Down-Regulation of Na+/K+/K+-ATPase Activity by Human Parvovirus B19 Capsid Protein VP1', linking it to cellular pathophysiology in infection. The finding has 8696 citations and relates to anemia in parvovirus B19 cases.
How is Parvovirus B19 associated with fetal hydrops?
Parvovirus B19 causes nonimmune hydrops fetalis through intrauterine infection and impaired erythropoiesis. The field description highlights its role in fetal hydrops and pregnancy complications. Clinical studies emphasize transmission and persistence leading to these outcomes.
What are the clinical implications of Parvovirus B19 in immunocompromised patients?
Parvovirus B19 persists in immunocompromised hosts, causing hematological disorders. Research covers viral transmission and pathogenesis in such individuals. Associations with rheumatic and autoimmune diseases are also documented in the 38,268 works.
How does virus-like particle technology relate to Parvovirus B19 studies?
Virus-like particle (VLP) technology from parvoviruses supports vaccine and diagnostic development. Peter Pushko et al. (2013) in 'Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures' describe VLP construction from non-enveloped viruses like parvovirus B19, with 5967 citations. This advances tools for parvovirus research.
What diagnostic criteria involve Parvovirus B19-related conditions?
Hemophagocytic lymphohistiocytosis (HLH) guidelines, potentially linked to viral triggers like parvovirus B19, include criteria such as fever, splenomegaly, and hemophagocytosis. Jan-Inge Henter et al. (2006) in 'HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis' updated these with three additional criteria, cited 5116 times. Parvovirus B19 studies explore such associations.
What is the scope of Parvovirus B19 research publications?
The field includes 38,268 works on infection, pathogenesis, and clinical implications. Key areas cover fetal hydrops, autoimmune diseases, and viral transmission. No five-year growth rate is reported.
Open Research Questions
- ? How does Parvovirus B19 VP1 protein-induced Na+/K+-ATPase down-regulation contribute to hydrops fetalis progression?
- ? What factors determine Parvovirus B19 persistence in immunocompetent versus immunocompromised hosts?
- ? Can virus-like particles from Parvovirus B19 be optimized for effective vaccines against pregnancy complications?
- ? What is the precise role of Parvovirus B19 in triggering autoimmune rheumatic disorders?
- ? How do intrauterine transmission dynamics of Parvovirus B19 influence nonimmune fetal hydrops outcomes?
Recent Trends
The field maintains 38,268 works with no reported five-year growth rate.
Top citations remain stable, led by Ahmad Almilaji et al. at 8696 for molecular mechanisms and Peter Pushko et al. (2013) at 5967 for VLP technology.
2013No recent preprints or news coverage in the last 12 months.
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