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Meningioma and schwannoma management
Research Guide
What is Meningioma and schwannoma management?
Meningioma and schwannoma management refers to the clinical strategies for treating meningiomas through surgical resection, radiosurgery, and monitoring for recurrence, alongside approaches for vestibular schwannomas that emphasize epidemiology, natural history, and treatment outcomes such as tumor control.
The field encompasses 52,861 papers on epidemiology, genomic analysis, histological classification, and treatment outcomes for meningiomas, including radiosurgery and surgical management. It also addresses the epidemiology and natural history of vestibular schwannomas, with focus on DNA methylation-based classification, tumor control, prognostic factors, and long-term follow-up after treatments. Growth rate over the past 5 years is not available in the data.
Topic Hierarchy
Research Sub-Topics
DNA Methylation Classification of Meningiomas
Researchers develop and validate epigenetic classifiers using genome-wide methylation arrays to stratify meningiomas into molecular subtypes with distinct clinical behaviors. Studies correlate methylation profiles with histological grades and progression risks.
Stereotactic Radiosurgery for Vestibular Schwannomas
This sub-topic evaluates long-term tumor control rates, hearing preservation, facial nerve outcomes, and quality-of-life metrics following Gamma Knife or CyberKnife radiosurgery. Comparative effectiveness trials assess single-session versus fractionated regimens.
Genomic Profiling of Meningioma Progression
Investigations apply whole-exome sequencing, RNA-seq, and copy number analysis to identify driver mutations (NF2, TERT, AKT1) and subclonal evolution in recurrent or malignant meningiomas. Research links genomics to therapeutic vulnerabilities.
Simpson Grade and Meningioma Recurrence
Studies analyze surgical extent of resection using Simpson grading against recurrence-free survival, incorporating modern neuroimaging and adjuvant therapies. Meta-analyses quantify recurrence risks across grades I-IV.
Natural History of Vestibular Schwannomas
Longitudinal cohort studies track growth rates, symptom progression, and observation outcomes in untreated vestibular schwannomas using serial MRI volumetrics. Research identifies predictors of rapid growth and intervention need.
Why It Matters
Management of meningiomas and schwannomas impacts patient survival and quality of life through optimized surgical and radiosurgical interventions. "THE RECURRENCE OF INTRACRANIAL MENINGIOMAS AFTER SURGICAL TREATMENT" by Simpson (1957) analyzed recurrence patterns post-surgery, informing decisions on reoperation timing in 2392 cited cases. For schwannomas, vestibular tumor natural history studies guide observation versus intervention, reducing unnecessary procedures while achieving tumor control, as evidenced by epidemiological data in the cluster.
Reading Guide
Where to Start
"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary" by Louis et al. (2016), as it provides foundational histological and molecular classification essential for understanding meningioma management.
Key Papers Explained
"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary" by Louis et al. (2016) establishes classification basics, which "THE RECURRENCE OF INTRACRANIAL MENINGIOMAS AFTER SURGICAL TREATMENT" by Simpson (1957) applies to surgical outcomes. "CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016" by Ostrom et al. (2019) contextualizes these with epidemiology, linking classification to population-level management.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Current work emphasizes DNA methylation-based classification and prognostic factors for meningioma and schwannoma tumor control, with focus on long-term follow-up after radiosurgery and surgery.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | The 2016 World Health Organization Classification of Tumors of... | 2016 | Acta Neuropathologica | 15.5K | ✓ |
| 2 | A multivariate analysis of 416 patients with glioblastoma mult... | 2001 | Journal of neurosurgery | 3.0K | ✕ |
| 3 | International subarachnoid aneurysm trial (ISAT) of neurosurgi... | 2005 | The Lancet | 2.8K | ✕ |
| 4 | SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX | 1944 | Journal of Neurophysio... | 2.6K | ✕ |
| 5 | CBTRUS Statistical Report: Primary Brain and Other Central Ner... | 2019 | Neuro-Oncology | 2.5K | ✓ |
| 6 | Neurocognition in patients with brain metastases treated with ... | 2009 | The Lancet Oncology | 2.4K | ✕ |
| 7 | Whole brain radiation therapy with or without stereotactic rad... | 2004 | The Lancet | 2.4K | ✕ |
| 8 | THE RECURRENCE OF INTRACRANIAL MENINGIOMAS AFTER SURGICAL TREA... | 1957 | Journal of Neurology N... | 2.4K | ✓ |
| 9 | Glioblastoma and Other Malignant Gliomas | 2013 | JAMA | 2.2K | ✕ |
| 10 | Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy v... | 2006 | JAMA | 2.2K | ✕ |
Frequently Asked Questions
What is the role of histological classification in meningioma management?
Histological classification guides prognosis and treatment in meningiomas. "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary" by Louis et al. (2016) updated criteria for central nervous system tumors, including meningiomas, with 15,475 citations. This system integrates molecular features for precise management.
How does surgical treatment affect meningioma recurrence?
"THE RECURRENCE OF INTRACRANIAL MENINGIOMAS AFTER SURGICAL TREATMENT" by Simpson (1957) documented recurrence rates following surgery. Factors like tumor location and resection extent influence outcomes. Long-term follow-up is essential for detecting regrowth.
What prognostic factors are considered in brain tumor management including meningiomas?
"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016" by Ostrom et al. (2019) provides incidence data for primary CNS tumors, including meningiomas. Prognostic factors encompass extent of resection and tumor histology. Population-based statistics aid in risk stratification.
What treatment modalities are used for vestibular schwannomas?
Vestibular schwannoma management includes observation, surgery, and radiosurgery based on natural history and epidemiology. The paper cluster highlights tumor control and long-term outcomes. Prognostic factors determine intervention thresholds.
How does radiosurgery contribute to meningioma treatment?
Radiosurgery achieves tumor control in meningiomas as part of management strategies. Papers in the cluster evaluate outcomes post-radiosurgery versus surgery. It serves as an alternative for inoperable cases.
Open Research Questions
- ? What DNA methylation profiles best predict meningioma recurrence after radiosurgery?
- ? Which prognostic factors most accurately forecast vestibular schwannoma growth during observation?
- ? How do histological subtypes influence long-term tumor control in surgically managed meningiomas?
- ? What genomic markers improve risk stratification for schwannoma treatment selection?
Recent Trends
The field maintains steady output with 52,861 papers, centering on genomic analysis, DNA methylation classification, and radiosurgery outcomes for meningiomas alongside vestibular schwannoma natural history.
No growth rate data over 5 years or recent preprints/news available.
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