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Nonmelanoma Skin Cancer Studies
Research Guide
What is Nonmelanoma Skin Cancer Studies?
Nonmelanoma Skin Cancer Studies is a field of medical research focused on the epidemiology, risk factors, incidence, and management of nonmelanoma skin cancers, including squamous cell carcinoma and basal cell carcinoma.
The field encompasses 51,719 published works examining sun exposure, organ transplant recipients, actinic keratoses, metastasis, photodynamic therapy, and imiquimod cream. Lomas et al. (2012) in "A systematic review of worldwide incidence of nonmelanoma skin cancer" reported NMSC as an increasing problem for health care services worldwide, highlighting needs for better registration standards. Rogers et al. (2015) in "Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012" estimated continued increases in US skin cancer diagnoses, with equal incidence rates for basal cell carcinoma and squamous cell carcinoma in the Medicare population.
Topic Hierarchy
Research Sub-Topics
Epidemiology of Basal Cell Carcinoma
This sub-topic analyzes incidence trends, risk factors including UV exposure, and demographic patterns of basal cell carcinoma (BCC), the most common skin cancer. Researchers study molecular subtypes and geographic variations.
Squamous Cell Carcinoma Risk Factors
This sub-topic investigates UVR, immunosuppression, HPV, and chemical exposures as risks for cutaneous squamous cell carcinoma (cSCC) progression to metastasis. Researchers conduct cohort studies in high-risk groups like transplant recipients.
Nonmelanoma Skin Cancer in Transplant Recipients
This sub-topic examines accelerated NMSC incidence, aggressive behavior, and management strategies in solid organ transplant patients under immunosuppression. Researchers evaluate chemoprevention and surveillance protocols.
Photodynamic Therapy for Actinic Keratoses
This sub-topic covers topical PDT protocols, efficacy, cosmesis, and pain management for field cancerization treatment of actinic keratoses preceding NMSC. Researchers compare ALA-PDT vs MAL-PDT in RCTs.
Topical Imiquimod for Nonmelanoma Skin Cancer
This sub-topic evaluates imiquimod 5% cream's immune-modulating efficacy for superficial BCC, actinic keratoses, and in situ SCC. Researchers study recurrence rates, inflammation mechanisms, and combination therapies.
Why It Matters
Nonmelanoma skin cancer studies inform public health strategies by quantifying incidence and risk factors, such as UV exposure linked to skin cancer epidemiology by Armstrong and Kricker (2001) in "The epidemiology of UV induced skin cancer". In organ transplant recipients, Euvrard et al. (2003) in "Skin Cancers after Organ Transplantation" identified skin cancers as the most common tumors, guiding targeted screening and management protocols. Rogers et al. (2015) provided a 2012 US incidence estimate showing rising diagnoses, with 3.3 million affected patients annually, supporting resource allocation for prevention and treatment like photodynamic therapy discussed by Brown et al. (2004) in "The present and future role of photodynamic therapy in cancer treatment".
Reading Guide
Where to Start
"Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012" by Rogers et al. (2015) provides a clear, data-driven US incidence estimate with specific numbers like 3.3 million affected patients, serving as an accessible entry to NMSC epidemiology.
Key Papers Explained
Lomas et al. (2012) in "A systematic review of worldwide incidence of nonmelanoma skin cancer" establishes global incidence trends, which Rogers et al. (2015) in "Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012" builds on with US-specific 2012 data showing rising diagnoses. Euvrard et al. (2003) in "Skin Cancers after Organ Transplantation" extends risk factor analysis to high-risk groups like transplant recipients, while Armstrong and Kricker (2001) in "The epidemiology of UV induced skin cancer" provides foundational UV exposure mechanisms. Esteva et al. (2017) in "Dermatologist-level classification of skin cancer with deep neural networks" introduces diagnostic AI advancements applicable to NMSC.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Research continues on incidence tracking improvements called for by Lomas et al. (2012) and risk stratification in transplant patients from Euvrard et al. (2003), with no recent preprints available to indicate shifts.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Dermatologist-level classification of skin cancer with deep ne... | 2017 | Nature | 12.8K | ✓ |
| 2 | Seria cultivation of strains of human epidemal keratinocytes: ... | 1975 | Cell | 4.5K | ✕ |
| 3 | Final Version of the American Joint Committee on Cancer Stagin... | 2001 | Journal of Clinical On... | 2.6K | ✕ |
| 4 | A systematic review of worldwide incidence of nonmelanoma skin... | 2012 | British Journal of Der... | 1.9K | ✕ |
| 5 | The epidemiology of UV induced skin cancer | 2001 | Journal of Photochemis... | 1.8K | ✕ |
| 6 | Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Ca... | 2015 | JAMA Dermatology | 1.8K | ✓ |
| 7 | The present and future role of photodynamic therapy in cancer ... | 2004 | The Lancet Oncology | 1.8K | ✕ |
| 8 | Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinoma... | 2014 | Journal of Investigati... | 1.7K | ✓ |
| 9 | Proportion and number of cancer cases and deaths attributable ... | 2017 | CA A Cancer Journal fo... | 1.6K | ✓ |
| 10 | Skin Cancers after Organ Transplantation | 2003 | New England Journal of... | 1.6K | ✕ |
Frequently Asked Questions
What is the worldwide incidence trend of nonmelanoma skin cancer?
NMSC represents an increasing problem for health care services worldwide. Lomas et al. (2012) in "A systematic review of worldwide incidence of nonmelanoma skin cancer" emphasized the need for prevention studies and improved NMSC registration standards to match those of other invasive diseases.
How high is the incidence of nonmelanoma skin cancer in the US?
Rogers et al. (2015) in "Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012" estimated continued increases in skin cancer diagnoses, affecting 3.3 million patients in 2012, with equal incidence rates for basal cell carcinoma and squamous cell carcinoma in the Medicare population.
What role does UV exposure play in skin cancer?
Armstrong and Kricker (2001) in "The epidemiology of UV induced skin cancer" detailed UV exposure as a key epidemiological factor in skin cancer development.
Why are skin cancers common in organ transplant recipients?
Euvrard et al. (2003) in "Skin Cancers after Organ Transplantation" stated that skin cancers are the most common tumors in organ transplant patients, covering squamous-cell carcinoma, basal-cell carcinoma, and others.
What is photodynamic therapy's role in skin cancer treatment?
Brown et al. (2004) in "The present and future role of photodynamic therapy in cancer treatment" examined photodynamic therapy's applications in managing cancers including nonmelanoma types.
What diagnostic advancements exist for skin cancer?
Esteva et al. (2017) in "Dermatologist-level classification of skin cancer with deep neural networks" achieved dermatologist-level accuracy using deep neural networks for skin cancer classification. Sierra et al. (2014) in "Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study" demonstrated confocal imaging-guided ablation for basal cell carcinomas.
Open Research Questions
- ? How can NMSC registration standards be improved globally to better track incidence as noted by Lomas et al. (2012)?
- ? What factors drive the equal BCC and SCC incidence rates in Medicare populations per Rogers et al. (2015)?
- ? How does UV exposure quantitatively contribute to NMSC risk across populations as analyzed by Armstrong and Kricker (2001)?
- ? What management strategies best reduce skin cancer rates in organ transplant recipients according to Euvrard et al. (2003)?
- ? Can confocal imaging-guided ablation be optimized for in vivo basal cell carcinoma treatment beyond Sierra et al. (2014) ex vivo results?
Recent Trends
The field includes 51,719 works with no specified 5-year growth rate; Rogers et al. documented continued US NMSC incidence increases to 3.3 million patients in 2012, aligning with Lomas et al. (2012) observations of worldwide rises, but no preprints or news from the last 12 months report further developments.
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