PapersFlow Research Brief
Tannin, Tannase and Anticancer Activities
Research Guide
What is Tannin, Tannase and Anticancer Activities?
Tannin, Tannase and Anticancer Activities refers to the study of tannins as polyphenolic compounds, tannase as the enzyme that hydrolyzes tannins to produce gallic acid, and their associated anticancer properties including antioxidant, antimutagenic, and chemopreventive effects.
The field encompasses 11,893 papers on tannase production via methods like solid-state fermentation, tannin biodegradation, and medical applications of gallic acid and tannins. Tannins exhibit antimicrobial properties as documented in 'Antimicrobial properties of tannins' by Scalbert (1991). Tannins and related polyphenols demonstrate anticancer activities through mechanisms such as antioxidant effects and inhibition of tumor promotion, as shown in papers on tea catechins and resveratrol.
Topic Hierarchy
Research Sub-Topics
Tannase Production Solid-State Fermentation
This sub-topic optimizes fungal and bacterial tannase yields using agro-industrial wastes in SSF processes. Researchers enhance enzyme activity through strain selection and media design.
Gallic Acid Anticancer Mechanisms
This sub-topic investigates gallic acid's induction of apoptosis, cell cycle arrest, and metastasis inhibition in cancer cell lines. Researchers elucidate signaling pathways like PI3K/Akt.
Microbial Tannase Purification Characterization
This sub-topic covers chromatography techniques, molecular weight determination, and kinetic properties of tannases from Aspergillus and Lactobacillus. Researchers classify tannase types I and II.
Tannase Biodegradation Tannin Pollutants
This sub-topic applies tannase for treating tannery and winery effluents rich in tannins. Researchers evaluate bioremediation efficiency and environmental toxicity reduction.
Tea Catechin Metabolism Anticancer Effects
This sub-topic studies EGCG hydrolysis by tannase, bioavailability, and chemopreventive actions via NF-κB inhibition. Researchers link metabolites to colorectal and breast cancer prevention.
Why It Matters
Tannins and their derivatives, including gallic acid from tannase hydrolysis, contribute to anticancer applications by acting as antioxidants and chemopreventive agents. For instance, resveratrol from grapes showed cancer chemopreventive activity across three stages of carcinogenesis in assays, as reported by Jang et al. (1997) in 'Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes' with 4901 citations. Green tea catechins prevented cytotoxicity and inhibited intercellular communication in studies by Ruch et al. (1989), supporting applications in cancer prevention. These properties extend to human health effects reviewed by Chung et al. (1998) in 'Tannins and Human Health: A Review', highlighting reduced protein digestibility alongside potential benefits in food science and medical contexts.
Reading Guide
Where to Start
'Tannins and Human Health: A Review' by Chung et al. (1998), as it provides a foundational overview of tannins' properties, health effects, and relevance to anticancer activities with 1948 citations.
Key Papers Explained
'Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes' by Jang et al. (1997, 4901 citations) establishes chemopreventive mechanisms similar to tannins; 'Antimicrobial properties of tannins' by Scalbert (1991, 2246 citations) details tannin bioactivity; 'Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea' by Ruch et al. (1989, 2052 citations) builds on this by showing polyphenol inhibition of tumor promotion; 'Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions' by Higdon and Frei (2003, 1838 citations) connects to metabolism; and 'Cancer prevention by tea: animal studies, molecular mechanisms and human relevance' by Yang et al. (2009, 1124 citations) extends to human applications.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Research emphasizes tannase in solid-state fermentation for gallic acid production and tannin biodegradation, with keywords like apoptosis and biosynthesis indicating focus on precise anticancer mechanisms. No recent preprints or news available, so frontiers involve extending polyphenol findings from top papers to tannase-specific therapies.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Colorimetric assay of catalase | 1972 | Analytical Biochemistry | 5.4K | ✕ |
| 2 | Cancer Chemopreventive Activity of Resveratrol, a Natural Prod... | 1997 | Science | 4.9K | ✕ |
| 3 | Antimicrobial properties of tannins | 1991 | Phytochemistry | 2.2K | ✕ |
| 4 | Prevention of cytotoxicity and inhibition of intercellular com... | 1989 | Carcinogenesis | 2.1K | ✕ |
| 5 | Tannins and Human Health: A Review | 1998 | Critical Reviews in Fo... | 1.9K | ✕ |
| 6 | Tea Catechins and Polyphenols: Health Effects, Metabolism, and... | 2003 | Critical Reviews in Fo... | 1.8K | ✕ |
| 7 | Molecular mechanisms underlying chemopreventive activities of ... | 2001 | Mutation research. Fun... | 1.6K | ✓ |
| 8 | Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechani... | 2011 | Biochemical Pharmacology | 1.5K | ✕ |
| 9 | Fumonisins--novel mycotoxins with cancer-promoting activity pr... | 1988 | Applied and Environmen... | 1.3K | ✓ |
| 10 | Cancer prevention by tea: animal studies, molecular mechanisms... | 2009 | Nature reviews. Cancer | 1.1K | ✕ |
Frequently Asked Questions
What role does tannase play in tannin research?
Tannase hydrolyzes tannins to produce gallic acid, enabling applications in biodegradation and medical uses. This enzyme production often occurs through solid-state fermentation. The resulting gallic acid contributes to antioxidant and anticancer activities.
How do tannins exhibit anticancer effects?
Tannins and related polyphenols like tea catechins act as antioxidants, inhibiting tumor promotion and cytotoxicity. 'Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea' by Ruch et al. (1989) showed green tea antioxidants blocking TPA-induced effects. These mechanisms include antimutagenic activity and phase II enzyme induction.
What are key applications of gallic acid from tannase?
Gallic acid supports anticancer, antioxidant, and medical applications following tannin hydrolysis by tannase. It appears in studies on tea polyphenols' health effects, as in 'Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions' by Higdon and Frei (2003). Biodegradation processes also utilize this product.
Which polyphenols show chemopreventive activity related to tannins?
Resveratrol, a phytoalexin akin to tannin-derived compounds, demonstrated chemopreventive activity in carcinogenesis assays per Jang et al. (1997). Tea catechins like EGCG exhibit similar effects through NF-κB suppression, as in Surh et al. (2001). These align with tannin anticancer research.
What health impacts do tannins have on humans?
Tannins reduce feed intake, growth rate, and protein digestibility in animals, as reviewed in 'Tannins and Human Health: A Review' by Chung et al. (1998). They also provide antimicrobial and potential anticancer benefits. Human relevance includes cancer prevention via tea polyphenols, per Yang et al. (2009).
Open Research Questions
- ? How does tannase optimize gallic acid yield for scalable anticancer applications?
- ? What specific molecular pathways link tannin hydrolysis products to apoptosis induction?
- ? Can tannin-derived antioxidants enhance chemotherapy efficacy without increasing resistance?
- ? Which fermentation methods maximize tannase activity for biodegradation and medical uses?
- ? How do structural variations in tannins influence their antimutagenic potency?
Recent Trends
The field maintains 11,893 works with no specified 5-year growth rate.
Top-cited papers from 1972-2011 highlight persistent interest in polyphenol anticancer mechanisms, such as resveratrol's activity in Jang et al. and tea catechins in Yang et al. (2009).
1997No recent preprints or news reported.
Research Tannin, Tannase and Anticancer Activities with AI
PapersFlow provides specialized AI tools for Immunology and Microbiology researchers. Here are the most relevant for this topic:
Systematic Review
AI-powered evidence synthesis with documented search strategies
AI Literature Review
Automate paper discovery and synthesis across 474M+ papers
Paper Summarizer
Get structured summaries of any paper in seconds
See how researchers in Life Sciences use PapersFlow
Field-specific workflows, example queries, and use cases.
Start Researching Tannin, Tannase and Anticancer Activities with AI
Search 474M+ papers, run AI-powered literature reviews, and write with integrated citations — all in one workspace.
See how PapersFlow works for Immunology and Microbiology researchers