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Structural and Chemical Analysis of Organic and Inorganic Compounds
Research Guide
What is Structural and Chemical Analysis of Organic and Inorganic Compounds?
Structural and chemical analysis of organic and inorganic compounds is the application of spectroscopic, chromatographic, and crystallographic methods to determine the molecular architecture, bonding, and reactivity of carbon-based and non-carbon-based substances, including heterocycles like oxadiazoles and thiadiazoles.
This field encompasses 25,966 published works focused on synthesis and analysis of heterocyclic compounds such as oxadiazoles, thiadiazoles, and fluorinated variants. Research emphasizes cycloaddition reactions, conformational analysis, and antimicrobial properties of these structures. Techniques reveal electronic structures and intramolecular interactions critical to their biological applications.
Topic Hierarchy
Research Sub-Topics
Oxadiazole Synthesis and Applications
This sub-topic covers 1,3,4-oxadiazole and 1,2,4-oxadiazole synthesis via cyclodehydration and cycloaddition, with antimicrobial screening. Researchers explore SAR for antibacterial and antifungal activity.
Thiadiazole Derivatives in Medicinal Chemistry
This sub-topic examines 1,3,4-thiadiazole and 2-amino-thiadiazole synthesis, focusing on anticancer, anti-inflammatory properties. Researchers study molecular docking and in vivo efficacy.
Cycloaddition Reactions in Heterocycle Synthesis
This sub-topic investigates [3+2] dipolar cycloadditions and Diels-Alder reactions forming heterocycles like triazoles and oxazoles. Researchers optimize regioselectivity and asymmetric catalysis.
Fluorinated Heterocyclic Compounds
This sub-topic covers synthesis of fluorinated oxadiazoles and thiadiazoles, analyzing fluorine's metabolic stability effects. Researchers use 19F NMR and X-ray crystallography for structural elucidation.
Conformational Analysis of Heterocycles
This sub-topic employs DFT calculations, NMR, and X-ray diffraction to study ring puckering and intramolecular interactions in heterocycles. Researchers correlate conformations with biological activity.
Why It Matters
Structural and chemical analysis enables design of druglike molecules by identifying bioisosteric replacements, as in oxadiazoles used in medicinal chemistry. Boström et al. (2011) in "Oxadiazoles in Medicinal Chemistry" describe how these five-membered rings with two carbons, two nitrogens, and one oxygen serve as motifs in pharmaceuticals, with 577 citations reflecting their impact. Analysis of chalcogen-bonding interactions, detailed by Pascoe et al. (2017) in "The Origin of Chalcogen-Bonding Interactions" with 515 citations, supports applications in catalysis and materials science. Mukherjee et al. (2010) in "Organoselenium Chemistry: Role of Intramolecular Interactions" (552 citations) highlight how such studies inform reactivity in organoselenium compounds for biological processes.
Reading Guide
Where to Start
"THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE THROUGH THE 2,4-DINITROPHENYLHYDRAZINE DERIVATIVE OF DEHYDROASCORBIC ACID" by Roe and Kuether (1943) introduces practical derivatization for structural analysis with 1784 citations and clear methodology.
Key Papers Explained
Roe and Kuether (1943) provide foundational derivatization techniques cited 1784 times, which Ingold (1953) builds upon in "Structure and Mechanism in Organic Chemistry" (1473 citations) for reaction mechanisms. The 1957 "Electronic Structure and Spectra of Nitrogen Heterocycles" (1216 citations) extends to spectral analysis, while Eicher et al. (2003) in "The Chemistry of Heterocycles" (1149 citations) and the 2008 "Comprehensive Heterocyclic Chemistry III" (1089 citations) synthesize these into heterocyclic frameworks. Boström et al. (2011) apply them to oxadiazoles (577 citations).
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Recent emphasis falls on chalcogen bonds per Pascoe et al. (2017, 515 citations) and organoselenium interactions from Mukherjee et al. (2010, 552 citations), targeting antimicrobial heterocycles. No preprints or news in last 12 months indicate steady progress via established methods.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE TH... | 1943 | Journal of Biological ... | 1.8K | ✓ |
| 2 | Structure and Mechanism in Organic Chemistry | 1953 | Medical Entomology and... | 1.5K | ✕ |
| 3 | Electronic Structure and Spectra of Nitrogen Heterocycles | 1957 | Zeitschrift für Physik... | 1.2K | ✕ |
| 4 | Chemistry and biology of pteridines | 1956 | Biochimica et Biophysi... | 1.2K | ✕ |
| 5 | The Chemistry of Heterocycles | 2003 | — | 1.1K | ✕ |
| 6 | Comprehensive Heterocyclic Chemistry III | 2008 | Elsevier eBooks | 1.1K | ✕ |
| 7 | Oxadiazoles in Medicinal Chemistry | 2011 | Journal of Medicinal C... | 577 | ✓ |
| 8 | S-ADENOSYLMETHIONINE; A NEW INTERMEDIATE FORMED ENZYMATICALLY ... | 1953 | Journal of Biological ... | 568 | ✓ |
| 9 | Organoselenium Chemistry: Role of Intramolecular Interactions | 2010 | Chemical Reviews | 552 | ✕ |
| 10 | The Origin of Chalcogen-Bonding Interactions | 2017 | Journal of the America... | 515 | ✓ |
Frequently Asked Questions
What are oxadiazoles in chemical analysis?
Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom in different regioisomeric forms. Boström et al. (2011) note their frequent use as bioisosteric replacements in druglike molecules. They appear in 577-cited work on medicinal chemistry applications.
How do chalcogen bonds form in compounds?
Chalcogen bonds arise from favorable interactions between group 16 elements, analogous to hydrogen and halogen bonds. Pascoe et al. (2017) in a 515-cited JACS paper trace their origin to molecular orbital overlaps in catalysis and biology. These bonds influence processes in materials and medicinal chemistry.
What role do intramolecular interactions play in organoselenium chemistry?
Intramolecular interactions stabilize organoselenium compounds and dictate reactivity. Mukherjee et al. (2010) review this in a 552-cited Chemical Reviews article from IIT Bombay researchers. Such analysis aids synthesis of biologically active heterocycles.
Why analyze electronic structures of nitrogen heterocycles?
Electronic structure analysis of nitrogen heterocycles reveals spectra and bonding patterns essential for synthesis. A 1957 Zeitschrift für Physikalische Chemie paper with 1216 citations details these properties. It supports conformational studies in modern heterocyclic chemistry.
What methods determine ascorbic acid in biological samples?
Roe and Kuether (1943) developed a method using 2,4-dinitrophenylhydrazine derivative of dehydroascorbic acid for ascorbic acid quantification in blood and urine. Their 1784-cited JBC paper established this derivative-based approach. It remains a reference for vitamin C structural analysis.
How does heterocyclic chemistry apply to pteridines?
Pteridines, analyzed in Fromageot (1956)'s 1208-cited Biochimica et Biophysica Acta paper, link chemistry to biology. Structural studies clarify their roles in biochemical pathways. This informs synthesis of related heterocycles like oxadiazoles.
Open Research Questions
- ? How can cycloaddition reactions of aza-oxyallyl cations be optimized for synthesizing fluorinated thiadiazoles?
- ? What conformational changes occur in oxadiazoles under biological conditions to enhance antimicrobial activity?
- ? Which intramolecular interactions best predict reactivity in organoselenium heterocycles?
- ? How do chalcogen bonds influence electronic spectra of nitrogen-containing inorganic compounds?
- ? What structural factors determine the bioisosteric efficacy of oxadiazoles in drug design?
Recent Trends
The field holds 25,966 works with sustained focus on oxadiazoles and thiadiazoles for antimicrobial uses, as in Boström et al. (2011, 577 citations).
High-impact papers like Pascoe et al. (2017, 515 citations) on chalcogen bonds and Mukherjee et al. (2010, 552 citations) on organoselenium drive analysis of intramolecular effects.
No growth rate, preprints, or news in last 12 months signals consolidation around cycloadditions and conformational studies.
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