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Respiratory and Cough-Related Research
Research Guide
What is Respiratory and Cough-Related Research?
Respiratory and Cough-Related Research is a field in pulmonary medicine that examines the diagnosis and management of chronic cough, encompassing cough reflex sensitivity, neuropathic disorders, vocal cord dysfunction, refractory chronic cough, cough hypersensitivity syndrome, laryngeal sensory neuropathy, airway afferent nerves, Pelargonium sidoides, and ambroxol.
The field includes 47,397 works focused on chronic cough mechanisms and treatments. Key areas cover cough reflex sensitivity and neuropathic disorders such as cough hypersensitivity syndrome and laryngeal sensory neuropathy. Growth rate over the past five years is not available in the provided data.
Topic Hierarchy
Research Sub-Topics
Cough Hypersensitivity Syndrome
This sub-topic examines cough hypersensitivity syndrome as a unified mechanism for refractory chronic cough involving peripheral and central sensitization. Researchers study capsaicin challenge tests and neuromodulator therapies.
Cough Reflex Sensitivity
This sub-topic investigates quantitative assessment of cough reflex thresholds using inhaled tussigens like capsaicin and citric acid. Researchers correlate hypersensitivity with clinical cough severity.
Laryngeal Sensory Neuropathy
This sub-topic covers laryngeal sensory dysfunction contributing to chronic refractory cough and laryngeal paraesthesia. Researchers use laryngoscopy and sensory testing for diagnosis and speech therapy outcomes.
Vocal Cord Dysfunction Cough
This sub-topic studies paradoxical vocal fold motion mimicking asthma and causing chronic cough misdiagnosis. Researchers develop diagnostic algorithms using spirometry and videostroboscopy.
Neuropathic Cough Mechanisms
This sub-topic explores damaged vagal afferent nerves and central cough pathway sensitization in chronic cough. Researchers use neuromodulators like gabapentin and amitriptyline in clinical trials.
Why It Matters
Respiratory and Cough-Related Research addresses chronic cough management, which affects diagnosis in conditions like refractory chronic cough and cough hypersensitivity syndrome. Guidelines such as "An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management" by Raghu et al. (2011) provide evidence-based approaches for related pulmonary conditions, cited 7099 times, aiding clinicians in interstitial lung diseases. In asthma contexts, "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008" by Bousquet et al. (2008), with 4631 citations, links upper airway issues to cough symptoms, impacting over 600 million patients worldwide with allergic rhinitis.
Reading Guide
Where to Start
"An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management" by Raghu et al. (2011), as it offers foundational evidence-based guidelines applicable to cough in pulmonary fibrosis contexts.
Key Papers Explained
Raghu et al. (2011) in "An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management" establishes diagnostic standards for fibrosis-related respiratory issues. Bousquet et al. (2008) in "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008" connects upper airway inflammation to cough-like symptoms in asthma. Celli et al. (2004) in "Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper" builds on these by updating COPD management, relevant to chronic cough in airflow limitation.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Research frontiers center on cough hypersensitivity syndrome and refractory chronic cough, with focus on airway afferent nerves and laryngeal sensory neuropathy. No recent preprints or news from the last 12 months are available.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary F... | 2011 | American Journal of Re... | 7.1K | ✓ |
| 2 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | 2008 | Allergy | 4.6K | ✓ |
| 3 | Standards for the diagnosis and treatment of patients with COP... | 2004 | European Respiratory J... | 4.4K | ✓ |
| 4 | Expert Panel Report 2: Guidelines for the Diagnosis and Manage... | 1997 | — | 4.1K | ✕ |
| 5 | International ERS/ATS guidelines on definition, evaluation and... | 2013 | European Respiratory J... | 3.8K | ✓ |
| 6 | A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pul... | 2014 | New England Journal of... | 3.8K | ✓ |
| 7 | Allergic Rhinitis and Its Impact on Asthma | 2001 | Journal of Allergy and... | 3.5K | ✕ |
| 8 | A Self-complete Measure of Health Status for Chronic Airflow L... | 1992 | American Review of Res... | 3.0K | ✕ |
| 9 | Leukotrienes: Mediators of Immediate Hypersensitivity Reaction... | 1983 | Science | 2.8K | ✕ |
| 10 | Development of the asthma control test | 2004 | Journal of Allergy and... | 2.8K | ✕ |
Frequently Asked Questions
What is cough hypersensitivity syndrome?
Cough hypersensitivity syndrome represents a unified diagnosis for chronic cough driven by increased sensitivity of airway nerves. It includes refractory chronic cough and links to laryngeal sensory neuropathy. Airway afferent nerves play a central role in this neuropathic disorder.
How is chronic cough diagnosed?
Diagnosis of chronic cough involves assessing cough reflex sensitivity and ruling out vocal cord dysfunction. Guidelines for related respiratory conditions emphasize evidence-based evaluation. Management targets underlying neuropathic mechanisms.
What treatments are used for refractory chronic cough?
Treatments for refractory chronic cough address cough hypersensitivity and airway afferent nerve dysfunction. Agents like Pelargonium sidoides and ambroxol target symptoms. These approaches stem from research on neuropathic cough disorders.
What role do airway afferent nerves play in cough?
Airway afferent nerves mediate cough reflex sensitivity in chronic cough conditions. They contribute to hypersensitivity syndromes and laryngeal sensory neuropathy. Targeting these nerves forms the basis for neuropathic disorder management.
How does vocal cord dysfunction relate to cough?
Vocal cord dysfunction mimics or exacerbates chronic cough symptoms. It requires differentiation from cough hypersensitivity syndrome. Diagnosis involves laryngoscopy alongside cough reflex assessment.
Open Research Questions
- ? How can cough reflex sensitivity be accurately measured in patients with neuropathic cough disorders?
- ? What distinguishes laryngeal sensory neuropathy from other causes of refractory chronic cough?
- ? Which neural pathways in airway afferent nerves most contribute to cough hypersensitivity syndrome?
- ? How effective are Pelargonium sidoides and ambroxol in long-term management of chronic cough?
Recent Trends
The field maintains 47,397 works with no specified five-year growth rate.
Emphasis persists on chronic cough, cough reflex sensitivity, and neuropathic disorders like cough hypersensitivity syndrome.
No recent preprints or news coverage from the last 12 months or six months alters these trends.
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