PapersFlow Research Brief
Pathogenesis and Treatment of Hiccups
Research Guide
What is Pathogenesis and Treatment of Hiccups?
Pathogenesis and Treatment of Hiccups refers to the study of the underlying mechanisms causing hiccups and the pharmacological and management strategies for treating them, particularly in contexts involving neurological disorders, palliative care, cardiac arrhythmias, and medications like gabapentin, corticosteroids, and vagus nerve stimulation.
This field encompasses 15,371 papers focused on the neurological basis of hiccups and their pharmacological treatments. Research highlights associations with neurological disorders and cardiac arrhythmias, alongside applications in palliative care. Growth rate over the past 5 years is not available.
Topic Hierarchy
Research Sub-Topics
Neurological Pathogenesis of Hiccups
This sub-topic investigates the central and peripheral neural mechanisms underlying persistent hiccups, including involvement of the vagus nerve and medullary respiratory centers. Researchers study lesions in neurological disorders like stroke and multiple sclerosis as triggers.
Gabapentin Treatment for Hiccups
Examines the efficacy and mechanisms of gabapentin in suppressing hiccups through GABAergic modulation in clinical trials and case series. Studies focus on dosage, response rates, and use in palliative settings.
Hiccups in Palliative Care
This area covers the management of hiccups as a distressing symptom in end-of-life care, including pharmacological and non-pharmacological approaches. Research evaluates impact on quality of life and multimodal interventions.
Hiccups and Cardiac Arrhythmias
Explores associations between hiccups and arrhythmias like atrial fibrillation, including shared vagal mechanisms and clinical outcomes. Studies analyze case reports and potential causal links in cardiovascular patients.
Vagus Nerve Stimulation for Hiccups
Investigates non-invasive and implantable vagus nerve stimulation as therapy for intractable hiccups, drawing from epilepsy protocols. Research assesses safety, efficacy, and neurophysiological effects.
Why It Matters
Pathogenesis and treatment research addresses hiccups in clinical settings such as palliative care for patients with neurological disorders and those experiencing cardiac arrhythmias. Studies emphasize medications like gabapentin and corticosteroids for management, with potential roles for vagus nerve stimulation and dopamine agonists. For instance, in palliative care, effective hiccup control improves patient comfort during serious illness, while understanding links to cardiac arrhythmias aids in preventing complications in affected individuals.
Reading Guide
Where to Start
"Chemotherapy-Induced Nausea and Vomiting" by Paul J. Hesketh (2008) provides an accessible entry due to its focus on related emetic mechanisms and antiemetic agents, offering foundational insights into reflex control relevant to hiccups.
Key Papers Explained
Top papers like "The Functional Gastrointestinal Disorders and the Rome III Process" by Douglas A. Drossman (2006) establish diagnostic frameworks for related symptoms, while "GSRS—A clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease" by Jan Svedlund et al. (1988) builds symptom assessment tools applicable to hiccup evaluation. "Chemotherapy-Induced Nausea and Vomiting" by Paul J. Hesketh (2008) connects to treatment strategies via antiemetic insights, linking to "Risk of Infectious Complications in Patients Taking Glucocorticosteroids" by Andreas E. Stuck et al. (1989), which details corticosteroid risks relevant to hiccup therapy.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Current research emphasizes pharmacological options like gabapentin and corticosteroids in neurological and palliative settings, with ongoing exploration of vagus nerve stimulation. No recent preprints or news coverage from the last 12 months or 6 months is available.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | The Functional Gastrointestinal Disorders and the Rome III Pro... | 2006 | Gastroenterology | 2.4K | ✕ |
| 2 | Measures of anxiety: State‐Trait Anxiety Inventory (STAI), Bec... | 2011 | Arthritis Care & Research | 1.7K | ✓ |
| 3 | GSRS?A clinical rating scale for gastrointestinal symptoms in ... | 1988 | Digestive Diseases and... | 1.4K | ✕ |
| 4 | Global Assessment of Functioning | 1995 | Psychosomatics | 1.1K | ✕ |
| 5 | Misoprostol Reduces Serious Gastrointestinal Complications in ... | 1995 | Annals of Internal Med... | 1.1K | ✕ |
| 6 | Irritable Bowel Syndrome | 2015 | JAMA | 1.1K | ✕ |
| 7 | Zur Theorie der Alkoholnarkose | 1899 | Naunyn-Schmiedeberg s ... | 1.0K | ✓ |
| 8 | Herbal Medicines and Perioperative Care | 2001 | JAMA | 967 | ✕ |
| 9 | Risk of Infectious Complications in Patients Taking Glucocorti... | 1989 | Clinical Infectious Di... | 824 | ✓ |
| 10 | Chemotherapy-Induced Nausea and Vomiting | 2008 | New England Journal of... | 803 | ✕ |
Frequently Asked Questions
What is the primary focus of research in pathogenesis and treatment of hiccups?
Research centers on the neurological basis of hiccups, their association with disorders like cardiac arrhythmias, and treatments in palliative care. Key pharmacological options include gabapentin, corticosteroids, and dopamine agonists. Vagus nerve stimulation represents a potential non-drug intervention.
How are hiccups treated pharmacologically?
Pharmacological treatments feature medications such as gabapentin and corticosteroids. Dopamine agonists are also considered in specific cases. These approaches target underlying mechanisms in neurological and palliative contexts.
What is the link between hiccups and neurological disorders?
Hiccups often arise from neurological dysfunction, as explored in this research cluster. Pathogenesis involves diaphragmatic and phrenic nerve irritation in such disorders. Treatments like gabapentin address these neurological origins effectively.
What role does vagus nerve stimulation play in hiccup management?
Vagus nerve stimulation is investigated as a treatment option for persistent hiccups. It targets the reflex arc involved in hiccup generation. This method shows promise alongside pharmacological agents in clinical management.
How many papers exist on hiccups pathogenesis and treatment?
There are 15,371 papers in this research cluster. They cover pathogenesis, pharmacological treatment, and management across medical contexts. No 5-year growth rate data is available.
Open Research Questions
- ? What specific neurological pathways trigger persistent hiccups in palliative care patients?
- ? How do cardiac arrhythmias directly contribute to hiccup pathogenesis?
- ? Which patient subgroups respond best to gabapentin versus corticosteroids for hiccups?
- ? Can vagus nerve stimulation replace pharmacological treatments in refractory cases?
- ? What are the long-term outcomes of dopamine agonist therapy for hiccup management?
Recent Trends
The field maintains 15,371 papers with no specified 5-year growth rate.
Focus persists on gabapentin, corticosteroids, vagus nerve stimulation, and links to cardiac arrhythmias, as no recent preprints or news from the last 6 or 12 months are available.
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