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Oral and Craniofacial Lesions
Research Guide
What is Oral and Craniofacial Lesions?
Oral and craniofacial lesions are pathological conditions affecting the oral cavity and craniofacial structures, including ankyloglossia, cysts, cleft lip and palate deformities, malocclusion, abfractions, and tumors such as sarcoma of the jaws.
The field encompasses 22,483 works on lesions like ankyloglossia (tongue-tie) and its effects on breastfeeding, speech articulation, and neonatal oral functions, along with treatments such as frenulotomy and laser frenectomy. Studies address cysts of the oral and maxillofacial regions, including odontogenic keratocyst, dentigerous cyst, and gingival cysts, as detailed in "Cysts of the Oral and Maxillofacial Regions" by Shear and Speight (2007). Research also covers enamel lesions, presurgical nasoalveolar molding for cleft lip and palate, and diagnostic tools like toluidine blue staining.
Topic Hierarchy
Research Sub-Topics
Ankyloglossia and Breastfeeding
This sub-topic studies the impact of tongue-tie on infant latch, milk transfer, and maternal pain during breastfeeding. Researchers evaluate prevalence, diagnosis, and outcomes post-frenotomy.
Frenulotomy Efficacy in Infants
Investigations assess the safety, short-term benefits, and long-term effects of lingual frenotomy procedures. Comparative studies include laser vs. scissors techniques and randomized trials.
Ankyloglossia and Speech Articulation
Researchers examine correlations between tongue-tie severity and speech sound disorders in children. Longitudinal studies track post-surgical articulation improvements.
Diagnosis of Lingual Frenulum Abnormalities
This area develops standardized assessment tools like the ATLFF scale for classifying ankyloglossia. Studies focus on inter-rater reliability and anatomical classifications.
Neonatal Implications of Ankyloglossia
Research explores broader effects on oral function, weight gain, and associated conditions like sleep apnea. Multidisciplinary approaches link to craniofacial development.
Why It Matters
Oral and craniofacial lesions impact breastfeeding, speech development, and dental health in infants and children, with ankyloglossia causing difficulties addressed by frenulotomy. "Presurgical Nasoalveolar Molding in Infants with Cleft Lip and Palate" by Grayson et al. (1999) improved outcomes in 605-cited cases by correcting cleft deformities neonatally, reducing surgical needs. "Cysts of the Oral and Maxillofacial Regions" by Shear and Speight (2007) classifies odontogenic keratocysts and dentigerous cysts, guiding maxillofacial surgery in 455-cited works. Toluidine blue staining, reviewed by Sridharan and Shankar (2012), detects oral premalignancies with high DNA/RNA affinity, aiding early diagnosis in clinical pathology. Abfractions from biomechanical stress, as classified by Grippo (1991), inform restorative dentistry for tooth substance loss.
Reading Guide
Where to Start
"Cysts of the Oral and Maxillofacial Regions" by Shear and Speight (2007) provides a foundational classification of common oral lesions like odontogenic keratocyst and dentigerous cyst, serving as an accessible entry for understanding lesion types and frequencies.
Key Papers Explained
"A sarcoma involving the jaws in african children" by Burkitt (1958) first described jaw sarcomas with 1318 citations, establishing tumor recognition. "Cysts of the Oral and Maxillofacial Regions" by Shear and Speight (2007) builds on pathology by classifying cysts including odontogenic keratocyst (455 citations). "Presurgical Nasoalveolar Molding in Infants with Cleft Lip and Palate" by Grayson et al. (1999) advances treatment paradigms (605 citations), while "Abfractions: A New Classification of Hard Tissue Lesions of Teeth" by Grippo (1991) introduces stress-related lesions (452 citations), connecting etiology across papers.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Research focuses on ankyloglossia effects on speech and breastfeeding, with treatments like frenulotomy and laser frenectomy central to neonatal care. No recent preprints or news available, so frontiers remain in lingual frenulum abnormalities and their functional impacts.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | A sarcoma involving the jaws in african children | 1958 | British journal of sur... | 1.3K | ✕ |
| 2 | Formation and resorption of three deciduous teeth in children | 1963 | American Journal of Ph... | 762 | ✕ |
| 3 | Alternating Demineralization and Remineralization of Artificia... | 1982 | Caries Research | 620 | ✕ |
| 4 | Presurgical Nasoalveolar Molding in Infants with Cleft Lip and... | 1999 | The Cleft Palate-Crani... | 605 | ✕ |
| 5 | The prevalence of malocclusion in Swedish schoolchildren | 1973 | European Journal Of Or... | 554 | ✕ |
| 6 | Cysts of the Oral and Maxillofacial Regions | 2007 | — | 455 | ✕ |
| 7 | Abfractions: A New Classification of Hard Tissue Lesions of Teeth | 1991 | Journal of Esthetic an... | 452 | ✕ |
| 8 | Diagnostic criteria for Walker‐Warburg syndrome | 1989 | American Journal of Me... | 448 | ✕ |
| 9 | Autotransplantation of teeth: requirements for predictable suc... | 2002 | Dental Traumatology | 442 | ✕ |
| 10 | Toluidine blue: A review of its chemistry and clinical utility | 2012 | Journal of Oral and Ma... | 435 | ✓ |
Frequently Asked Questions
What are cysts of the oral and maxillofacial regions?
Cysts include gingival cyst of infants, odontogenic keratocyst, dentigerous cyst, eruption cyst, gingival cyst of adults, lateral periodontal cyst, botryoid odontogenic cyst, and glandular odontogenic cyst. "Cysts of the Oral and Maxillofacial Regions" by Shear and Speight (2007) details their classification and frequency. These lesions arise in oral tissues and require specific diagnostic and surgical management.
How does presurgical nasoalveolar molding treat cleft lip and palate?
Presurgical nasoalveolar molding applies infant orthopedics to correct cleft lip and palate deformities neonatally. "Presurgical Nasoalveolar Molding in Infants with Cleft Lip and Palate" by Grayson et al. (1999) describes a method shifting from traditional approaches to improve alignment. It facilitates better surgical outcomes in infants.
What is abfraction in hard tissue lesions?
Abfraction is loss of enamel and dentin due to biomechanical loading forces like clenching and chewing. "Abfractions: A New Classification of Hard Tissue Lesions of Teeth" by Grippo (1991) defines it as stress-dependent chipping. It requires management to prevent further tooth substance erosion.
What is the role of toluidine blue in oral lesions?
Toluidine blue is a thiazine dye with affinity for DNA/RNA-rich tissues, used for vital staining in oral lesions. "Toluidine blue: A review of its chemistry and clinical utility" by Sridharan and Shankar (2012) outlines its metachromatic properties. It aids detection of premalignant conditions.
What causes alternating demineralization and remineralization in enamel lesions?
pH cycling with de- and remineralizing solutions induces mineral loss and uptake in artificial enamel lesions. "Alternating Demineralization and Remineralization of Artificial Enamel Lesions" by ten Cate and Duijsters (1982) varied fluoride presence and ratios. Fluoride enhances remineralization rates.
What is the prevalence of malocclusion in children?
Malocclusion prevalence was studied in 6,398 Swedish schoolchildren aged 7, 10, and 13 years. "The prevalence of malocclusion in Swedish schoolchildren" by Thilander and Myrberg (1973) examined urban and rural groups. Findings inform orthodontic planning.
Open Research Questions
- ? How do lingual frenulum abnormalities quantitatively affect speech articulation metrics in children beyond ankyloglossia?
- ? What are the long-term success rates of laser frenectomy compared to traditional frenulotomy for neonatal breastfeeding outcomes?
- ? Which molecular markers distinguish melanotic neuroectodermal tumor from other craniofacial lesions in infants?
- ? How does biomechanical stress magnitude predict abfraction progression in diverse populations?
- ? What genetic factors link Walker-Warburg syndrome craniofacial features to oral lesion severity?
Recent Trends
The field includes 22,483 works with growth data unavailable, maintaining focus on ankyloglossia, frenulotomy, and tongue-tie since classics like Burkitt.
1958No recent preprints or news in the last 6-12 months indicate steady rather than accelerating publication rates.
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