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Medicinal Plant Studies
Research Guide
What is Medicinal Plant Studies?
Medicinal Plant Studies is the scientific investigation of the medicinal uses, phytochemistry, and pharmacological properties of plants such as Clinacanthus nutans, recognized for its anti-inflammatory, antioxidant, and cytotoxic effects.
The field encompasses 15,907 published works focused on Clinacanthus nutans, covering ethnopharmacological applications, bioactive compounds, and potential treatments for conditions like hepatocellular carcinoma. Key research examines extraction methods for phenolic compounds from C. nutans leaves, optimizing temperature, time, and solvent ratios to enhance anti-radical activity, as shown in a 2017 study with 306 citations. Studies also explore immunomodulatory effects of traditional Chinese herbs including species relevant to this cluster.
Topic Hierarchy
Research Sub-Topics
Clinacanthus Nutans Phytochemistry
Researchers identify and characterize flavonoids, phenolics, triterpenoids, and clerodane diterpenes using HPLC, GC-MS, and NMR spectroscopy. Studies optimize extraction methods via response surface methodology.
Clinacanthus Nutans Anti-Inflammatory Activity
Investigations test extracts in LPS-induced models, NO inhibition assays, and cytokine modulation studies. Research elucidates pathways involving NF-κB, COX-2, and MAPK signaling.
Clinacanthus Nutans Antioxidant Properties
Studies employ DPPH, ABTS, FRAP assays and cellular oxidative stress models to quantify radical scavenging capacities. Research correlates phenolic content with antioxidant efficacy.
Clinacanthus Nutans Anticancer Effects
Cytotoxicity screening against breast, liver, and colon cancer cell lines uses MTT assays and apoptosis markers. In vivo xenograft models test tumor growth inhibition and safety.
Clinacanthus Nutans Ethnopharmacology
Documentation compiles traditional Southeast Asian uses for snakebites, skin lesions, diabetes, and viral infections. Clinical studies validate efficacy in herpes simplex and wound healing.
Why It Matters
Medicinal Plant Studies supports development of cosmeceutical products from Clinacanthus nutans leaf extracts, where response surface methodology optimized extraction conditions for phenolic compounds and anti-radical activity (Intan Soraya Che Sulaiman et al., 2017). Research on traditional Chinese herbs demonstrates immunomodulatory and antimicrobial effects, with reports on Aloe vera, Angelica species, Astragalus membranaceus, and Ganoderma supporting immune system applications (Benny Kwong‐Huat Tan and J. Vanitha, 2004). These findings contribute to pharmacological evaluations of phytochemical constituents for anti-inflammatory and cytotoxic uses in treating hepatocellular carcinoma.
Reading Guide
Where to Start
"Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology" (2017) introduces core extraction methods and their optimization for C. nutans, providing practical entry into phytochemistry with clear methodology and results.
Key Papers Explained
"Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology" (Intan Soraya Che Sulaiman et al., 2017, 306 citations) establishes extraction optimization for C. nutans antioxidants. "Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review" (Benny Kwong‐Huat Tan and J. Vanitha, 2004, 405 citations) contextualizes pharmacological properties of related herbs. "Prenylated Flavonoids: Pharmacology and Biotechnology" (Bruno Botta et al., 2005, 302 citations) builds on flavonoid structures relevant to C. nutans bioactive compounds.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Current research emphasizes cytotoxic applications of C. nutans against hepatocellular carcinoma through detailed phytochemical profiling. No recent preprints or news available, so frontiers remain in scaling extraction methods from Che Sulaiman et al. (2017) to clinical pharmacological trials.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Chlorinated drinking-water; chlorination by-products; some oth... | 1991 | PubMed | 534 | ✓ |
| 2 | Life cycle assessment of hydrogen fuel production processes | 2004 | International Journal ... | 424 | ✕ |
| 3 | Immunomodulatory and Antimicrobial Effects of Some Traditional... | 2004 | Current Medicinal Chem... | 405 | ✕ |
| 4 | Characteristics and composition of Parkia biglobbossa and Jatr... | 2003 | Bioresource Technology | 322 | ✕ |
| 5 | Effects of temperature, time, and solvent ratio on the extract... | 2017 | Chemistry Central Journal | 306 | ✓ |
| 6 | Prenylated Flavonoids: Pharmacology and Biotechnology | 2005 | Current Medicinal Chem... | 302 | ✕ |
| 7 | State of municipal solid waste management in Delhi, the capita... | 2007 | Waste Management | 259 | ✕ |
| 8 | Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry,... | 2020 | Journal of Ethnopharma... | 222 | ✕ |
| 9 | Methods for Obtaining and Determination of Squalene from Natur... | 2015 | BioMed Research Intern... | 210 | ✓ |
| 10 | Cities as environments | 1997 | Urban Ecosystems | 204 | ✕ |
Frequently Asked Questions
What are the main properties of Clinacanthus nutans studied in this field?
Clinacanthus nutans exhibits anti-inflammatory, antioxidant, and cytotoxic properties. Research focuses on its phytochemical constituents and bioactive compounds. These properties support potential applications in treating hepatocellular carcinoma.
How are phenolic compounds extracted from Clinacanthus nutans leaves?
Extraction uses response surface methodology, varying temperature, time, and solvent ratio. This method maximizes phenolic compound yield and anti-radical activity from C. nutans Lindau leaves. Optimized conditions aid cosmeceutical product development (Intan Soraya Che Sulaiman et al., 2017).
What immunomodulatory effects do traditional Chinese medicinal herbs show?
Herbs like Aloe vera Mill., Angelica species, Astragalus membranaceus Bunge, and Ganoderma lucidum provide immunomodulatory and antimicrobial effects. These are based on centuries-old traditions for immune support and infection control. Reviews confirm their pharmacological potential (Benny Kwong‐Huat Tan and J. Vanitha, 2004).
What topics does Medicinal Plant Studies cover for Clinacanthus nutans?
Topics include ethnopharmacological uses, phytochemistry, and pharmacological properties. Studies address bioactive compounds and cytotoxicity against hepatocellular carcinoma. The field totals 15,907 papers on these aspects.
Why is Clinacanthus nutans relevant to cosmeceuticals?
Its leaf extracts yield high phenolic compounds with anti-radical activity under optimized extraction. Response surface methodology determined ideal temperature, time, and solvent parameters. This supports cosmeceutical formulations (Intan Soraya Che Sulaiman et al., 2017).
Open Research Questions
- ? How do optimized extraction parameters for Clinacanthus nutans phenolic compounds influence in vivo anti-inflammatory efficacy?
- ? What specific bioactive compounds in Clinacanthus nutans contribute most to cytotoxicity against hepatocellular carcinoma cells?
- ? Can immunomodulatory mechanisms of traditional herbs like Astragalus membranaceus enhance Clinacanthus nutans pharmacological effects?
- ? What are the long-term stability profiles of prenylated flavonoids from medicinal plants under varying storage conditions?
Recent Trends
The cluster holds 15,907 works with no specified 5-year growth rate.
High-citation papers from 2017 like "Effects of temperature, time, and solvent ratio..." (Intan Soraya Che Sulaiman et al., 306 citations) sustain focus on C. nutans extraction.
No recent preprints or news reported.
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