PapersFlow Research Brief
Kruppel-like factors research
Research Guide
What is Kruppel-like factors research?
Kruppel-like factors research examines the functions of Krüppel-like factors as transcription factors that regulate gene expression, cell growth, differentiation, and processes such as cancer progression, endothelial activation, proinflammatory signaling, stem cell maintenance, and smooth muscle differentiation.
Kruppel-like factors research includes 16,861 published works focused on their roles in transcriptional regulation. These factors act in cancer, where they function as tumor suppressors, and in endothelial activation linked to vascular processes. Studies also address their contributions to proinflammatory signaling and stem cell maintenance.
Topic Hierarchy
Research Sub-Topics
Krüppel-like Factor 4 in Stem Cell Pluripotency
Researchers examine KLF4's role in maintaining embryonic stem cell pluripotency through target gene regulation and interaction with core transcription factors. Studies explore epigenetic modifications and reprogramming efficiency.
Krüppel-like Factors in Cancer Tumor Suppression
This sub-topic investigates KLFs (especially KLF4, KLF6) as tumor suppressors via cell cycle arrest, apoptosis induction, and metastasis inhibition. Research identifies downstream pathways and epigenetic silencing in cancers.
Kruppel-like Factors in Endothelial Activation
Scientists study KLF2 and KLF4 regulation of endothelial inflammation, thrombosis, and vascular tone through NF-κB inhibition and eNOS activation. Work links shear stress mechanotransduction to KLF expression.
Krüppel-like Factors in Smooth Muscle Differentiation
Research explores KLF4 and KLF5 roles in phenotypic switching between contractile and synthetic smooth muscle cells during vascular injury and development. Studies focus on SRF/myocardin pathway interactions.
Krüppel-like Factors in Proinflammatory Signaling
This area examines KLF repression of inflammatory cytokines (IL-6, TNF-α) in macrophages and endothelial cells via histone deacetylation and Stat signaling interference. Research addresses metabolic syndrome links.
Why It Matters
Kruppel-like factors research impacts cancer treatment through their roles as tumor suppressors and regulators of angiogenesis, as explored in vascular disease contexts. For instance, Folkman (1995) in "Angiogenesis in cancer, vascular, rheumatoid and other disease" detailed how angiogenesis drives tumor growth, with 7647 citations highlighting its influence on therapies targeting vascular endothelial growth factor signaling. In signaling pathways relevant to cancer and differentiation, Shi and Massagué (2003) in "Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus" (5809 citations) outlined TGF-β pathways intersecting with Kruppel-like factor activities in cell growth control. Clevers (2006) in "Wnt/β-Catenin Signaling in Development and Disease" (5499 citations) connected Wnt signaling to disease states involving stem cells and smooth muscle differentiation regulated by these factors.
Reading Guide
Where to Start
"Angiogenesis in cancer, vascular, rheumatoid and other disease" by Folkman (1995) provides an accessible entry point with 7647 citations, introducing vascular regulation central to Kruppel-like factor roles in endothelial activation and cancer.
Key Papers Explained
Folkman (1995) "Angiogenesis in cancer, vascular, rheumatoid and other disease" establishes angiogenesis foundations relevant to Kruppel-like factor-mediated endothelial activation. Shi and Massagué (2003) "Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus" builds by detailing TGF-β pathways intersecting with Kruppel-like transcriptional control in differentiation. Clevers (2006) "Wnt/β-Catenin Signaling in Development and Disease" extends to Wnt signaling components influencing stem cells and cancer, where Kruppel-like factors operate. MacDonald et al. (2009) "Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases" refines mechanisms, and Clevers and Nusse (2012) "Wnt/β-Catenin Signaling and Disease" updates disease applications.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Research emphasizes Kruppel-like factors in transcriptional regulation of cancer and stem cells, with highly cited works on Wnt/β-catenin and TGF-β signaling providing core frameworks. No recent preprints from the last 6 months or news from the last 12 months indicate ongoing developments.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Angiogenesis in cancer, vascular, rheumatoid and other disease | 1995 | Nature Medicine | 7.6K | ✕ |
| 2 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus | 2003 | Cell | 5.8K | ✓ |
| 3 | Wnt/β-Catenin Signaling in Development and Disease | 2006 | Cell | 5.5K | ✓ |
| 4 | Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases | 2009 | Developmental Cell | 5.5K | ✓ |
| 5 | Wnt/β-Catenin Signaling and Disease | 2012 | Cell | 5.4K | ✓ |
| 6 | Angiogenesis in health and disease | 2003 | Nature Medicine | 4.2K | ✕ |
| 7 | TGFβ in Cancer | 2008 | Cell | 3.8K | ✓ |
| 8 | TGF-β signalling from cell membrane to nucleus through SMAD pr... | 1997 | Nature | 3.7K | ✕ |
| 9 | TGFβ signalling in context | 2012 | Nature Reviews Molecul... | 3.0K | ✕ |
| 10 | VEGF receptor signalling ? in control of vascular function | 2006 | Nature Reviews Molecul... | 3.0K | ✕ |
Frequently Asked Questions
What roles do Krüppel-like factors play in cancer?
Krüppel-like factors regulate gene expression and act as tumor suppressors in cancer. They control cell growth and are involved in angiogenesis processes central to tumor development. Research connects them to pathways like TGF-β and Wnt/β-catenin signaling.
How do Krüppel-like factors contribute to endothelial activation?
Krüppel-like factors participate in endothelial activation through transcriptional regulation of proinflammatory signaling. This links to vascular function and angiogenesis in diseases. Papers like "Angiogenesis in cancer, vascular, rheumatoid and other disease" by Folkman (1995) describe related vascular mechanisms.
What is the involvement of Krüppel-like factors in stem cells?
Krüppel-like factors maintain stem cells by regulating differentiation and gene expression. They intersect with Wnt/β-catenin signaling pathways key to stem cell functions. Clevers (2006) in "Wnt/β-Catenin Signaling in Development and Disease" covers these signaling components.
How many papers exist on Krüppel-like factors research?
There are 16,861 works in Kruppel-like factors research. Growth rate over the past 5 years is not available. The field centers on molecular biology topics like transcriptional regulation and cancer.
What signaling pathways interact with Krüppel-like factors?
Krüppel-like factors interact with TGF-β and Wnt/β-catenin signaling in regulating cell processes. Shi and Massagué (2003) detailed TGF-β mechanisms from membrane to nucleus. Clevers and Nusse (2012) in "Wnt/β-Catenin Signaling and Disease" addressed disease implications.
What is the current state of Krüppel-like factors research?
Kruppel-like factors research totals 16,861 papers with no reported 5-year growth rate. No recent preprints or news coverage from the last 12 months are available. Focus remains on cancer, stem cells, and vascular signaling.
Open Research Questions
- ? How do Krüppel-like factors specifically integrate with Wnt/β-catenin signaling to control stem cell maintenance in cancer contexts?
- ? What mechanisms allow Krüppel-like factors to act as tumor suppressors while modulating proinflammatory signaling in endothelial cells?
- ? In what ways do Krüppel-like factors regulate smooth muscle differentiation through interactions with TGF-β pathways?
- ? How do context-specific roles of Krüppel-like factors differ in vascular diseases versus cancer progression?
- ? What are the precise transcriptional targets of Krüppel-like factors in angiogenesis and cell growth control?
Recent Trends
Kruppel-like factors research comprises 16,861 works with no 5-year growth rate available.
No recent preprints from the last 6 months or news coverage in the last 12 months are reported.
Citation leaders remain Folkman at 7647 for angiogenesis, Shi and Massagué (2003) at 5809 for TGF-β signaling, and Clevers (2006) at 5499 for Wnt/β-catenin pathways.
1995Research Kruppel-like factors research with AI
PapersFlow provides specialized AI tools for Biochemistry, Genetics and Molecular Biology researchers. Here are the most relevant for this topic:
AI Literature Review
Automate paper discovery and synthesis across 474M+ papers
Paper Summarizer
Get structured summaries of any paper in seconds
Deep Research Reports
Multi-source evidence synthesis with counter-evidence
See how researchers in Life Sciences use PapersFlow
Field-specific workflows, example queries, and use cases.
Start Researching Kruppel-like factors research with AI
Search 474M+ papers, run AI-powered literature reviews, and write with integrated citations — all in one workspace.
See how PapersFlow works for Biochemistry, Genetics and Molecular Biology researchers