PapersFlow Research Brief
Intestinal Malrotation and Obstruction Disorders
Research Guide
What is Intestinal Malrotation and Obstruction Disorders?
Intestinal malrotation and obstruction disorders are a cluster of congenital and acquired gastrointestinal conditions including intestinal malrotation, pyloric stenosis, colonic volvulus, duodenal atresia, and acute colonic pseudo-obstruction, often managed with interventions such as laparoscopic surgery, neostigmine treatment, or addressing genetic factors like TTC7A mutations.
This field encompasses 39,142 published works on disorders such as intestinal malrotation, pyloric stenosis, colonic volvulus, duodenal atresia, and acute colonic pseudo-obstruction. Studies address genetic mutations like TTC7A and treatments including neostigmine and laparoscopic surgery. Growth rate over the past five years is not available in the provided data.
Topic Hierarchy
Research Sub-Topics
Intestinal Malrotation Diagnosis and Management
Studies evaluate imaging modalities like upper GI series and ultrasound, Ladd's procedure outcomes, and long-term complications such as volvulus recurrence in pediatric and adult populations.
Pyloric Stenosis Pathophysiology and Treatment
Researchers investigate hypertrophic pyloric muscle etiology, ultrasound diagnostic criteria, and Ramstedt pyloromyotomy techniques including laparoscopic versus open approaches.
Colonic Volvulus Surgical Interventions
This area covers sigmoid and cecal volvulus epidemiology, endoscopic detorsion efficacy, and definitive surgeries like resection with primary anastomosis versus colostomy.
Duodenal Atresia Repair Techniques
Studies assess diamond-shaped duodenoduodenostomy, associated Down syndrome outcomes, and long-term gastrointestinal function following prenatal diagnosis advancements.
Acute Colonic Pseudo-Obstruction Therapy
Researchers evaluate neostigmine pharmacokinetics, colonoscopic decompression success rates, and risk stratification for cecal perforation in Ogilvie's syndrome management.
Why It Matters
These disorders contribute to significant morbidity in neonatal and pediatric populations, with conditions like necrotizing enterocolitis (NEC) requiring staged interventions to prevent progression, as detailed in "Neonatal Necrotizing Enterocolitis" (1978) where 48 infants were treated based on clinical staging from Stage I supportive measures to Stage III surgical resection. Guidelines such as "Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America" (2009) provide evidence-based protocols for managing associated infections, replacing prior 2002 and 2003 versions and impacting surgical decision-making in over 1,500 citations. Laparoscopic approaches and neostigmine for acute colonic pseudo-obstruction and sigmoid volvulus reduce complications, as classified in "Proposed classification of complications of surgery with examples of utility in cholecystectomy" (1992), which differentiates complications from sequelae to standardize reporting in abdominal surgeries.
Reading Guide
Where to Start
"Neonatal Necrotizing Enterocolitis" (1978) is the recommended starting paper as it introduces a practical clinical staging system for infants with intestinal obstruction complications, providing foundational treatment principles applicable to malrotation and related disorders.
Key Papers Explained
"Neonatal Necrotizing Enterocolitis" (Bell et al., 1978) establishes staging for NEC treatment in 48 infants, which "Necrotizing Enterocolitis: Treatment Based on Staging Criteria" (Walsh and Kliegman, 1986) builds upon for pediatric guidelines. "Proposed classification of complications of surgery with examples of utility in cholecystectomy" (Clavien et al., 1992) extends this by standardizing complication reporting for surgical interventions like those in volvulus. "Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America" (Solomkin et al., 2009) integrates these into infection management protocols.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Current frontiers focus on neostigmine applications for acute colonic pseudo-obstruction and TTC7A mutation studies in congenital anomalies like malrotation and duodenal atresia, with emphasis on laparoscopic refinements. No recent preprints or news from the last 12 months are available, indicating reliance on established guidelines such as those from Solomkin et al. (2009).
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | The “Golden Age” of Probiotics: A Systematic Review and Meta-A... | 2017 | Neonatology | 24.5K | ✕ |
| 2 | Neonatal Necrotizing Enterocolitis | 1978 | Annals of Surgery | 3.4K | ✓ |
| 3 | Clinically Oriented Anatomy | 1985 | — | 2.2K | ✕ |
| 4 | IAP/APA evidence-based guidelines for the management of acute ... | 2013 | Pancreatology | 2.0K | ✓ |
| 5 | Necrotizing Enterocolitis: Treatment Based on Staging Criteria | 1986 | Pediatric Clinics of N... | 1.8K | ✓ |
| 6 | Ulcerative Colitis Practice Guidelines in Adults (Update): Ame... | 2004 | The American Journal o... | 1.8K | ✕ |
| 7 | The inheritance of liability to certain diseases, estimated fr... | 1965 | Annals of Human Genetics | 1.7K | ✕ |
| 8 | Proposed classification of complications of surgery with examp... | 1992 | PubMed | 1.6K | ✕ |
| 9 | Diagnosis and Management of Complicated Intra-abdominal Infect... | 2009 | Clinical Infectious Di... | 1.5K | ✕ |
| 10 | The classification of cancer of the rectum | 1932 | The Journal of Patholo... | 1.5K | ✕ |
Frequently Asked Questions
What staging system is used for necrotizing enterocolitis in intestinal obstruction disorders?
A clinical staging system for necrotizing enterocolitis divides cases into Stage I (vigorous diagnostic and supportive measures), Stage II (antibiotics and hyperalimentation), and Stage III (surgical intervention), as proposed in "Neonatal Necrotizing Enterocolitis" (1978) based on 48 infants. This approach guides graded treatment to improve outcomes in preterm infants with intestinal obstruction.
How are complications classified in surgeries for intestinal malrotation and obstruction?
"Proposed classification of complications of surgery with examples of utility in cholecystectomy" (1992) defines complications as new problems from procedures, sequelae as expected postoperative states, and failures as inadequate results. This system standardizes reporting for procedures like laparoscopic surgery in colonic volvulus.
What guidelines exist for managing intra-abdominal infections related to obstruction disorders?
"Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America" (2009) offers evidence-based recommendations for adults and children, updating 2002 and 2003 versions. These protocols address infections in conditions like duodenal atresia and acute colonic pseudo-obstruction.
What treatments are discussed for acute colonic pseudo-obstruction?
Neostigmine treatment is highlighted for acute colonic pseudo-obstruction and sigmoid volvulus within this cluster. It provides non-surgical decompression, reducing the need for operative intervention in these obstruction disorders.
What role does laparoscopic surgery play in these disorders?
Laparoscopic surgery is used for conditions like intestinal malrotation and colonic volvulus, offering minimally invasive correction of congenital anomalies. It aligns with complication classification systems to minimize postoperative issues.
Open Research Questions
- ? How can TTC7A mutations be targeted therapeutically in intestinal malrotation and related congenital anomalies?
- ? What are optimal staging criteria for surgical intervention in acute colonic pseudo-obstruction versus volvulus?
- ? How do probiotics influence outcomes in preterm infants prone to necrotizing enterocolitis from malrotation?
- ? What refinements are needed in laparoscopic techniques for duodenal atresia repair to reduce complications?
- ? How does neostigmine efficacy vary across sigmoid volvulus presentations in adults and children?
Recent Trends
The field includes 39,142 works with no specified five-year growth rate; probiotics have gained attention via "The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants" (Dermyshi et al., 2017, 24,464 citations), linking to NEC prevention in obstruction-prone neonates.
No recent preprints or news coverage in the last 12 months is available.
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