Subtopic Deep Dive
Basidiobolomycosis Pathology
Research Guide
What is Basidiobolomycosis Pathology?
Basidiobolomycosis pathology studies the histopathologic features and clinical manifestations of subcutaneous and gastrointestinal infections caused by Basidiobolus ranarum in humans and animals.
Basidiobolomycosis presents as eosinophilic granulomatous abscesses in gastrointestinal tracts or subcutaneous tissues. Key papers document cases in dogs (Okada et al., 2015, 9 citations), humans in endemic areas (Brun et al., 2018, 4 citations), and genomic traits of the pathogen (Henk and Fisher, 2012, 22 citations). Over 10 papers from 1986-2022 characterize its pathology, often mimicking tumors or other mycoses.
Why It Matters
Basidiobolomycosis challenges tropical veterinary and human medicine with deep eosinophilic granulomas misdiagnosed as cancer (Taha et al., 2011) or fascioliasis (Hassan et al., 2013). In animals, it causes fatal gastrointestinal masses in dogs (Okada et al., 2015) and pythiosis-like lesions in horses (Headley and Arruda, 2004). Zoonotic risks from geckos (Martin et al., 2022) and gut colonization (Henk and Fisher, 2012) demand better antifungal profiles amid limited treatments.
Key Research Challenges
Diagnostic Mimicry
Basidiobolomycosis mimics colon cancer (Taha et al., 2011) or Buruli ulcer (Brun et al., 2018), delaying diagnosis without PCR confirmation. Eosinophilic granulomas overlap with toxocariasis (Hassan et al., 2013).
Antifungal Resistance
Basidiobolus ranarum resists standard antifungals, as seen in veterinary cases requiring surgery (Okada et al., 2015; Sukanan et al., 2022). Systemic spread complicates therapy (Benbow and Stoddart, 1986).
Zoonotic Reservoir ID
Linking animal carriers like geckos (Martin et al., 2022) to human GI cases (Hassan et al., 2013) remains unclear. Large genome aids persistence (Henk and Fisher, 2012).
Essential Papers
Neglected fungal zoonoses: hidden threats to man and animals
Seyedmojtaba Seyedmousavi, Jacques Guillot, Ali Tolooe et al. · 2015 · Clinical Microbiology and Infection · 83 citations
Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan
Hemmin A Hassan, Runnak A Majid, Nawshirwan Rashid et al. · 2013 · BMC Infectious Diseases · 39 citations
Abstract Background Deep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commo...
Systemic zygomycosis
E W Benbow, R. W. Stoddart · 1986 · Postgraduate Medical Journal · 25 citations
Journal Article Systemic zygomycosis Get access E W Benbow, E W Benbow Department of Pathology, University of Manchester, Oxford Road, Manchester M13 9PT, UK Correspondence: E.W. Benbow B.Sc., M.B....
Equine cutaneous pythiosis: a report of four cases
Selwyn Arlington Headley, Homero Neves Arruda · 2004 · Ciência Rural · 23 citations
Cutaneous pythiosis is described in four horses in Northern Paraná, Brazil. All animals presented ulcerative, granulomatous, cutaneous lesions that did not invade adjacent muscular tissues. Histopa...
The Gut Fungus Basidiobolus ranarum Has a Large Genome and Different Copy Numbers of Putatively Functionally Redundant Elongation Factor Genes
Daniel A. Henk, Matthew C. Fisher · 2012 · PLoS ONE · 22 citations
Fungal genomes range in size from 2.3 Mb for the microsporidian Encephalitozoon intestinalis up to 8000 Mb for Entomophaga aulicae, with a mean genome size of 37 Mb. Basidiobolus, a common inhabita...
Gastrointestinal basidiobolomycosis in a dog
Kazuki Okada, Shinjiro Amano, Yoshio Kawamura et al. · 2015 · Journal of Veterinary Medical Science · 9 citations
An 8-year-old, spayed, female Shiba dog was presented to a referring veterinarian with a complaint of chronic diarrhea and anorexia. Ultrasound and radiographs revealed an irregular mass in the pel...
Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin
Luc Brun, Jean-Jacques Roux, Ghislain Emmanuel Sopoh et al. · 2018 · Case Reports in Pathology · 4 citations
Background . Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. M...
Reading Guide
Foundational Papers
Start with Hassan et al. (2013, 39 citations) for GI/hepatic eosinophilic abscesses; Henk and Fisher (2012, 22 citations) for Basidiobolus ranarum genome; Benbow and Stoddart (1986, 25 citations) for systemic zygomycosis context.
Recent Advances
Brun et al. (2018) on subcutaneous cases in Benin; Martin et al. (2022) linking geckos to human disease; Sukanan et al. (2022) on pythiosis management parallels.
Core Methods
Histopathology (eosinophilic granulomas), PCR for species ID (Martin et al., 2022), genome sequencing (Henk and Fisher, 2012), ultrasound/radiography for masses (Okada et al., 2015).
How PapersFlow Helps You Research Basidiobolomycosis Pathology
Discover & Search
Research Agent uses searchPapers and exaSearch to find cases like Okada et al. (2015) on canine GI basidiobolomycosis; citationGraph reveals clusters from Hassan et al. (2013, 39 citations); findSimilarPapers links zoonotic papers to Seyedmousavi et al. (2015).
Analyze & Verify
Analysis Agent applies readPaperContent to extract histopathology from Brun et al. (2018), verifies claims with CoVe against Henk and Fisher (2012) genome data, and runs PythonAnalysis for citation trend stats using pandas on 250M+ OpenAlex papers; GRADE scores evidence strength for diagnostic PCR.
Synthesize & Write
Synthesis Agent detects gaps in antifungal trials via gap detection on Sukanan et al. (2022); Writing Agent uses latexEditText, latexSyncCitations for pathology reports, and latexCompile for figures; exportMermaid diagrams granuloma pathways from Headley and Arruda (2004).
Use Cases
"Analyze eosinophil counts in basidiobolomycosis histopathology across veterinary cases"
Research Agent → searchPapers → Analysis Agent → runPythonAnalysis (pandas aggregation of counts from Okada 2015, Headley 2004) → matplotlib plot of granuloma metrics.
"Draft LaTeX review of GI basidiobolomycosis mimicking tumors"
Synthesis Agent → gap detection → Writing Agent → latexEditText + latexSyncCitations (Hassan 2013, Taha 2011) → latexCompile → PDF with cited case tables.
"Find code for Basidiobolus genome analysis from papers"
Research Agent → paperExtractUrls (Henk 2012) → paperFindGithubRepo → githubRepoInspect → Python scripts for EF gene copy numbers.
Automated Workflows
Deep Research workflow scans 50+ papers via searchPapers → citationGraph on Hassan (2013), yielding structured pathology report. DeepScan's 7-steps verify zoonosis claims (Martin 2022) with CoVe checkpoints. Theorizer generates hypotheses on antifungal resistance from Okada (2015) and Sukanan (2022).
Frequently Asked Questions
What defines basidiobolomycosis pathology?
Eosinophilic granulomatous inflammation in subcutaneous or GI tissues from Basidiobolus ranarum, confirmed by PCR (Brun et al., 2018).
What are main diagnostic methods?
Histopathology shows granulomas with Splendore-Hoeppli material; PCR identifies Basidiobolus (Martin et al., 2022; Okada et al., 2015).
What are key papers?
Hassan et al. (2013, 39 citations) on hepatic abscesses; Henk and Fisher (2012, 22 citations) on genome; Okada et al. (2015, 9 citations) on canine GI case.
What open problems exist?
Antifungal susceptibility profiles, zoonotic transmission from reptiles (Martin et al., 2022), and systemic therapy efficacy (Benbow and Stoddart, 1986).
Research Infectious Diseases and Mycology with AI
PapersFlow provides specialized AI tools for Veterinary researchers. Here are the most relevant for this topic:
AI Literature Review
Automate paper discovery and synthesis across 474M+ papers
Deep Research Reports
Multi-source evidence synthesis with counter-evidence
Paper Summarizer
Get structured summaries of any paper in seconds
AI Academic Writing
Write research papers with AI assistance and LaTeX support
See how researchers in Health & Medicine use PapersFlow
Field-specific workflows, example queries, and use cases.
Start Researching Basidiobolomycosis Pathology with AI
Search 474M+ papers, run AI-powered literature reviews, and write with integrated citations — all in one workspace.
See how PapersFlow works for Veterinary researchers
Part of the Infectious Diseases and Mycology Research Guide