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Infectious Aortic and Vascular Conditions
Research Guide
What is Infectious Aortic and Vascular Conditions?
Infectious aortic and vascular conditions are infections affecting vascular grafts, mycotic aneurysms, prosthetic grafts, and aortoenteric fistulas, managed through endovascular repair, diagnostic imaging, surgical interventions, and antibiotic treatments.
This field encompasses 15,426 papers on vascular graft infections and related conditions. Management strategies include endovascular stent-graft placement and surgical procedures for prosthetic graft infections and mycotic aneurysms. Long-term outcomes depend on prolonged antibiotic treatment combined with repeated surgeries.
Topic Hierarchy
Research Sub-Topics
Vascular Graft Infections Management
Researchers evaluate antibiotic regimens, surgical debridement, and conservative treatments for prosthetic vascular graft infections. Long-term studies assess reinfection rates and graft preservation strategies.
Mycotic Aortic Aneurysms
This sub-topic covers microbiology, pathogenesis, and outcomes of bacterial and fungal-infected aortic aneurysms. Research compares open repair versus endovascular approaches in ruptured cases.
Endovascular Repair of Infected Aneurysms
Studies assess stent-graft placement for aortoenteric fistulas and graft infections, including adjunctive antibiotic strategies. Meta-analyses evaluate durability and complication profiles versus open surgery.
Aortoenteric Fistula Diagnosis
Research develops improved imaging protocols using CT angiography and endoscopy for early detection of aortoenteric fistulas. Diagnostic accuracy studies differentiate infection from other enteric pathologies.
Long-term Outcomes of Vascular Infections
Longitudinal cohort studies track survival, reinfection, and quality of life after treatment of prosthetic infections and mycotic aneurysms. Risk factor analyses guide secondary prevention.
Why It Matters
Infections associated with surgical implants like vascular grafts affect about half of nosocomial infections and often require extended antibiotic therapy alongside multiple surgeries, as detailed in Rabih O. Darouiche (2004) 'Treatment of Infections Associated with Surgical Implants'. Endovascular stent-grafts provide a nonsurgical option for descending thoracic aortic aneurysms, showing safety in selected patients per Michael D. Dake et al. (1994) 'Transluminal Placement of Endovascular Stent-Grafts for the Treatment of Descending Thoracic Aortic Aneurysms'. These approaches impact surgical practice by reducing operative risks in thoracic aortic dissections, with elective stent-graft insertion demonstrating efficacy in Christoph Nienaber et al. (1999) 'Nonsurgical Reconstruction of Thoracic Aortic Dissection by Stent–Graft Placement'.
Reading Guide
Where to Start
Start with 'Treatment of Infections Associated with Surgical Implants' by Rabih O. Darouiche (2004) because it provides a foundational review of device-associated infections central to vascular graft management, covering diagnosis and treatment essentials.
Key Papers Explained
Rabih O. Darouiche (2004) 'Treatment of Infections Associated with Surgical Implants' establishes the challenges of implant infections requiring antibiotics and surgery. Michael D. Dake et al. (1994) 'Transluminal Placement of Endovascular Stent-Grafts for the Treatment of Descending Thoracic Aortic Aneurysms' introduces endovascular repair as a safer alternative to open surgery. Christoph Nienaber et al. (1999) 'Nonsurgical Reconstruction of Thoracic Aortic Dissection by Stent–Graft Placement' extends this to dissections, while Lars G. Svensson et al. (2008) 'Expert Consensus Document on the Treatment of Descending Thoracic Aortic Disease Using Endovascular Stent-Grafts' synthesizes evidence into guidelines.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Current efforts focus on refining endovascular techniques for complicated cases like mycotic aneurysms and aortoenteric fistulas, building on consensus from Svensson et al. (2008). No recent preprints or news indicate ongoing refinements in antibiotic protocols and imaging for long-term outcomes.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Treatment of Infections Associated with Surgical Implants | 2004 | New England Journal of... | 2.2K | ✕ |
| 2 | Transluminal Placement of Endovascular Stent-Grafts for the Tr... | 1994 | New England Journal of... | 1.7K | ✓ |
| 3 | Abdominal aortic aneurysm | 2005 | The Lancet | 1.1K | ✓ |
| 4 | Nonsurgical Reconstruction of Thoracic Aortic Dissection by St... | 1999 | New England Journal of... | 1.0K | ✓ |
| 5 | Yearly rupture or dissection rates for thoracic aortic aneurys... | 2002 | The Annals of Thoracic... | 1.0K | ✕ |
| 6 | Thoracic and Abdominal Aortic Aneurysms | 2005 | Circulation | 986 | ✓ |
| 7 | Matrix metalloproteinases 2 and 9 work in concert to produce a... | 2002 | Journal of Clinical In... | 982 | ✓ |
| 8 | Changing Profile of Infective Endocarditis<SUBTITLE>Resu... | 2002 | JAMA | 980 | ✕ |
| 9 | Expert Consensus Document on the Treatment of Descending Thora... | 2008 | The Annals of Thoracic... | 853 | ✕ |
| 10 | Thoracic aortic aneurysms: a population-based study. | 1982 | PubMed | 837 | ✕ |
Frequently Asked Questions
What are the main challenges in treating infections of vascular grafts?
Infections linked to implanted surgical devices demand prolonged antibiotic treatment and repeated surgical interventions. Rabih O. Darouiche (2004) in 'Treatment of Infections Associated with Surgical Implants' notes these infections account for half of nosocomial cases and complicate management.
How is endovascular repair used for aortic aneurysms?
Transluminal placement of endovascular stent-grafts treats descending thoracic aortic aneurysms safely in selected patients. Michael D. Dake et al. (1994) in 'Transluminal Placement of Endovascular Stent-Grafts for the Treatment of Descending Thoracic Aortic Aneurysms' report preliminary success requiring long-term evaluation. Similar results apply to thoracic aortic dissections via nonsurgical stent-graft placement.
What role do antibiotics play in prosthetic graft infections?
Antibiotic treatment is essential for long-term management of prosthetic graft infections alongside surgery. Rabih O. Darouiche (2004) 'Treatment of Infections Associated with Surgical Implants' emphasizes its necessity due to the difficulty in eradicating device-associated infections.
What are the outcomes of stent-grafts in thoracic aortic disease?
Endovascular stent-grafts offer safe and efficacious repair for descending thoracic aortic disease in indicated cases. Lars G. Svensson et al. (2008) in 'Expert Consensus Document on the Treatment of Descending Thoracic Aortic Disease Using Endovascular Stent-Grafts' provides consensus on their application. Christoph Nienaber et al. (1999) confirm efficacy for aortic dissections.
How common are thoracic aortic aneurysms?
Thoracic aortic aneurysms occurred at an age- and sex-adjusted incidence of 5.9 per 100,000 person-years over 30 years in one population. Bickerstaff et al. (1982) in 'Thoracic aortic aneurysms: a population-based study' found equal rates in men and women with a slight decline over time.
Open Research Questions
- ? What are the precise roles and interactions of matrix metalloproteinases 2 and 9 in producing infectious aortic aneurysms?
- ? How do yearly rupture or dissection rates for thoracic aortic aneurysms vary by size in infected cases?
- ? What long-term outcomes arise from combining antibiotic treatment with endovascular repair in vascular graft infections?
- ? How effective is nonsurgical stent-graft placement for managing aortoenteric fistulas?
- ? What diagnostic imaging advances improve detection of mycotic aneurysms?
Recent Trends
The field maintains 15,426 works with no specified 5-year growth rate.
Highly cited papers from 1982 to 2008, such as Bickerstaff et al. 'Thoracic aortic aneurysms: a population-based study' reporting 5.9 per 100,000 incidence, continue to anchor research.
1982No recent preprints or news coverage in the last 12 months signal steady focus on established endovascular and surgical methods.
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