Subtopic Deep Dive
Pediatric Intussusception Treatment Outcomes
Research Guide
What is Pediatric Intussusception Treatment Outcomes?
Pediatric intussusception treatment outcomes evaluate success rates of air or contrast enema reductions (80-95%), recurrence risks, surgical thresholds, and mortality trends in idiopathic versus pathologic cases post-rotavirus vaccination.
Comparative studies analyze enema reduction efficacy, with idiopathic cases showing higher non-surgical success than pathologic ones requiring lead point evaluation (Jiang et al., 2013; 276 citations). National databases track declining mortality after rotavirus vaccines (Clark et al., 2019; 64 citations). Japanese guidelines recommend prompt ultrasound diagnosis and enema attempts (Ito et al., 2012; 82 citations).
Why It Matters
Enema reduction success of 80-95% reduces surgical needs in children, but recurrence risks up to 10-15% demand lead point identification to prevent complications (Guo et al., 2017; 84 citations). Post-rotavirus vaccination surveillance shows stable or reduced intussusception incidence, informing global immunization policies (Jiang et al., 2013). Optimizing treatment thresholds via imaging and risk factors improves outcomes in recurrent cases (Plut et al., 2020; 66 citations).
Key Research Challenges
Distinguishing idiopathic vs pathologic
Pathologic lead points in 5-30% of cases require surgical resection, unlike idiopathic ones amenable to enema (Marsicovetere et al., 2016; 599 citations). Delayed identification increases morbidity (Ito et al., 2012).
Predicting recurrence risks
Recurrence after enema affects 10-15% of patients; risk factors like age <6 months and symptoms duration guide repeat interventions (Guo et al., 2017; 84 citations).
Post-vaccination monitoring
Tracking intussusception rates pre- and post-rotavirus vaccine needs large-scale epidemiology to assess causality (Clark et al., 2019; 64 citations; Jiang et al., 2013).
Essential Papers
Intussusception of the bowel in adults: A review
Athanasios Marinis, Anneza Yiallourou, Lazaros Samanides et al. · 2009 · World Journal of Gastroenterology · 811 citations
Intussusception of the bowel is defined as the telescoping of a proximal segment of the gastrointestinal tract within the lumen of the adjacent segment. This condition is frequent in children and p...
Intestinal Intussusception: Etiology, Diagnosis, and Treatment
Priscilla Marsicovetere, Srinivas Joga Ivatury, Brent C. White et al. · 2016 · Clinics in Colon and Rectal Surgery · 599 citations
Intussusception is defined as the invagination of one segment of the bowel into an immediately adjacent segment of the bowel. Idiopathic ileocolic intussusception is the most common form in childre...
Childhood Intussusception: A Literature Review
James Jiang, Baoming Jiang, Umesh D. Parashar et al. · 2013 · PLoS ONE · 276 citations
This review of the intussusception literature from the past decade provides pertinent information that should facilitate implementation of intussusception surveillance for monitoring the postlicens...
Intussusception in adults: Clinical characteristics, diagnosis and operative strategies
Savaş Yakan, Cemil Çalışkan, Özer Makay et al. · 2009 · World Journal of Gastroenterology · 241 citations
Adult intussusception is an unusual and challenging condition and is a preoperative diagnostic problem. Treatment usually requires resection of the involved bowel segment. Reduction can be attempte...
Intussusception due to inflammatory fibroid polyp: A case report and comprehensive literature review
Sami Akbulut · 2012 · World Journal of Gastroenterology · 106 citations
Although IFPs are rare and benign, surgery is the only solution in case of intestinal obstruction. Differential diagnosis should be made via immunohistochemical examination.
Adult Intussusception
Teng Lü, Yi-Mei Chng · 2015 · The Permanente Journal · 92 citations
Recurrent abdominal pain is a common and challenging presenting chief complaint in the Emergency Department. Intussusception in adults, although rare, is an important etiology to consider. The diag...
Risk factors for recurrent intussusception in children: a retrospective cohort study
Wan‐liang Guo, Zhang-chun Hu, Ya-lan Tan et al. · 2017 · BMJ Open · 84 citations
Objective The aim of this study was to assess the frequency of clinical features and pathological lead points in recurrent intussusception, with a special focus on the risk factors that lead to rec...
Reading Guide
Foundational Papers
Start with Jiang et al. (2013; 276 citations) for rotavirus surveillance context, Ito et al. (2012; 82 citations) for pediatric guidelines, and Marsicovetere et al. (2016; 599 citations) for etiology-treatment overview.
Recent Advances
Study Guo et al. (2017; 84 citations) for recurrence risks, Clark et al. (2019; 64 citations) for global epidemiology, and Plut et al. (2020; 66 citations) for imaging strategies.
Core Methods
Air/contrast enema reduction, ultrasound diagnosis, risk stratification for recurrence (age, symptoms), epidemiological tracking via national databases.
How PapersFlow Helps You Research Pediatric Intussusception Treatment Outcomes
Discover & Search
Research Agent uses searchPapers and exaSearch to find pediatric-focused papers like 'Risk factors for recurrent intussusception in children' (Guo et al., 2017), then citationGraph reveals connections to rotavirus surveillance (Jiang et al., 2013) and findSimilarPapers uncovers database analyses.
Analyze & Verify
Analysis Agent applies readPaperContent to extract enema success rates from Ito et al. (2012), verifies claims with CoVe against national trends in Clark et al. (2019), and uses runPythonAnalysis for GRADE grading of recurrence risks or statistical meta-analysis of 80-95% reduction rates via pandas.
Synthesize & Write
Synthesis Agent detects gaps in pathologic vs idiopathic outcomes, flags contradictions in adult-child differences (Marinis et al., 2009), and Writing Agent uses latexEditText, latexSyncCitations for Guo et al. (2017), latexCompile reports, with exportMermaid for treatment decision flowcharts.
Use Cases
"Meta-analyze enema success rates and recurrence from pediatric intussusception studies"
Research Agent → searchPapers + exaSearch → Analysis Agent → runPythonAnalysis (pandas meta-analysis of rates from Ito et al. 2012, Guo et al. 2017) → GRADE-verified CSV export of pooled 80-95% success.
"Write LaTeX review on post-rotavirus intussusception outcomes"
Synthesis Agent → gap detection in Jiang et al. 2013 + Clark et al. 2019 → Writing Agent → latexEditText + latexSyncCitations + latexCompile → formatted PDF with citations and outcome tables.
"Find code for intussusception risk prediction models"
Research Agent → paperExtractUrls on Guo et al. 2017 → Code Discovery → paperFindGithubRepo + githubRepoInspect → Python sandbox verification of recurrence factor models.
Automated Workflows
Deep Research workflow conducts systematic review of 50+ intussusception papers: searchPapers → citationGraph → DeepScan 7-step analysis with CoVe checkpoints on enema efficacy. Theorizer generates hypotheses on vaccination impacts from Jiang et al. (2013) and Clark et al. (2019) trends. DeepScan verifies recurrence risk factors across Guo et al. (2017) cohorts.
Frequently Asked Questions
What defines pediatric intussusception treatment outcomes?
Outcomes measure enema reduction success (80-95%), recurrence (10-15%), surgical rates, and mortality, distinguishing idiopathic from pathologic cases (Marsicovetere et al., 2016).
What are standard treatment methods?
Air/contrast enema first-line for idiopathic cases per Japanese guidelines; surgery for failures or lead points (Ito et al., 2012; 82 citations).
What are key papers?
Foundational: Jiang et al. (2013; 276 citations) on surveillance; Guo et al. (2017; 84 citations) on recurrence risks; Ito et al. (2012; 82 citations) guidelines.
What open problems exist?
Predicting pathologic lead points pre-enema, standardizing recurrence risk models, and long-term post-vaccination epidemiology (Clark et al., 2019; Guo et al., 2017).
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