Subtopic Deep Dive
Intussusception Diagnosis and Imaging
Research Guide
What is Intussusception Diagnosis and Imaging?
Intussusception diagnosis and imaging encompasses ultrasound, CT, and MRI identification of bowel telescoping, target sign, and lead points in pediatric and adult cases to differentiate transient from pathologic forms.
Intussusception involves invagination of one bowel segment into another, common in children as idiopathic ileocolic type and rare in adults often with lead points like tumors (Marinis et al., 2009, 811 citations). CT provides highest diagnostic accuracy, showing classic target or sausage signs, while ultrasound excels in pediatrics (Wang et al., 2009, 278 citations). Over 50 papers detail multimodality features and accuracy.
Why It Matters
Timely imaging diagnosis allows non-operative reduction in pediatric ileocolic intussusception, avoiding surgery and reducing morbidity (Marsicovetere et al., 2016, 599 citations). In adults, CT identifies lead points like GISTs, guiding resection and improving outcomes (Yakan et al., 2009, 241 citations; Rammohan, 2012, 188 citations). Accurate differentiation of transient from pathologic cases prevents unnecessary interventions (Yalamarthi and Smith, 2005, 240 citations).
Key Research Challenges
Lead Point Identification
Distinguishing pathologic lead points like tumors from idiopathic cases requires high-resolution imaging, but small lesions evade detection on ultrasound (Wang et al., 2009). CT excels but misses early mucosal changes (Huang and Warshauer, 2003). Over 200 papers note diagnostic delays in adults.
Transient vs Pathologic
Differentiating self-resolving transient intussusception from surgical cases challenges ultrasound specificity in children (Marsicovetere et al., 2016). Follow-up imaging adds burden without standardized criteria (Sangüesa Nebot et al., 2018, 155 citations).
Adult Presentation Variability
Adults present with nonspecific symptoms delaying preoperative diagnosis, unlike pediatric triad (Marinis et al., 2009). Multimodality needed but guidelines lack consensus (Yakan et al., 2009).
Essential Papers
Intussusception of the bowel in adults: A review
Athanasios Marinis, Anneza Yiallourou, Lazaros Samanides et al. · 2009 · World Journal of Gastroenterology · 811 citations
Intussusception of the bowel is defined as the telescoping of a proximal segment of the gastrointestinal tract within the lumen of the adjacent segment. This condition is frequent in children and p...
Intestinal Intussusception: Etiology, Diagnosis, and Treatment
Priscilla Marsicovetere, Srinivas Joga Ivatury, Brent C. White et al. · 2016 · Clinics in Colon and Rectal Surgery · 599 citations
Intussusception is defined as the invagination of one segment of the bowel into an immediately adjacent segment of the bowel. Idiopathic ileocolic intussusception is the most common form in childre...
Adult intussusception: A retrospective review of 41 cases
Ning Wang, Xingyu Cui, Yü Liu et al. · 2009 · World Journal of Gastroenterology · 278 citations
CT is the most effective and accurate diagnostic technique. Colonoscopy can detect most lead point lesions of non-enteric intussusceptions. Intestinal intubation should be avoided.
Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott et al. · 2022 · Endoscopy · 272 citations
Main Recommendations MR1 ESGE recommends small-bowel capsule endoscopy as the first-line examination, before consideration of other endoscopic and radiological diagnostic tests for suspected small-...
Intussusception in adults: Clinical characteristics, diagnosis and operative strategies
Savaş Yakan, Cemil Çalışkan, Özer Makay et al. · 2009 · World Journal of Gastroenterology · 241 citations
Adult intussusception is an unusual and challenging condition and is a preoperative diagnostic problem. Treatment usually requires resection of the involved bowel segment. Reduction can be attempte...
Adult intussusception: case reports and review of literature
S. Yalamarthi, Robert C. Smith · 2005 · Postgraduate Medical Journal · 240 citations
Abstract Adult intussusception occurs infrequently and differs from childhood intussusception in its presentation, aetiology, and treatment. Diagnosis can be delayed because of its longstanding, in...
A gist of gastrointestinal stromal tumors: A review
Ashwin Rammohan · 2012 · World Journal of Gastrointestinal Oncology · 188 citations
Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They const...
Reading Guide
Foundational Papers
Start with Marinis et al. (2009, 811 citations) for definitions and adult review, then Wang et al. (2009, 278 citations) for CT evidence, Yalamarthi and Smith (2005, 240 citations) for case differences.
Recent Advances
Marsicovetere et al. (2016, 599 citations) on etiology/treatment; Pennazio et al. (2022, 272 citations) on endoscopy adjuncts; Sangüesa Nebot et al. (2018, 155 citations) on cysts.
Core Methods
Ultrasound (pediatric target sign), CT (gold standard accuracy), MRI (soft tissue lead points), endoscopy for non-enteric lesions (Wang et al., 2009; Huang and Warshauer, 2003).
How PapersFlow Helps You Research Intussusception Diagnosis and Imaging
Discover & Search
Research Agent uses searchPapers for 'intussusception CT target sign adults' retrieving Marinis et al. (2009, 811 citations), then citationGraph maps 200+ citing works on adult diagnostics, and findSimilarPapers uncovers Huang and Warshauer (2003) for imaging hallmarks.
Analyze & Verify
Analysis Agent applies readPaperContent on Wang et al. (2009) to extract CT accuracy metrics, verifyResponse with CoVe cross-checks claims against 10 similar papers, and runPythonAnalysis computes pooled sensitivity (95% CI) from extracted data using pandas; GRADE grading scores evidence as high for CT diagnostics.
Synthesize & Write
Synthesis Agent detects gaps in pediatric ultrasound protocols versus adult CT, flags contradictions on reduction safety (Yalamarthi and Smith, 2005), then Writing Agent uses latexEditText for review drafting, latexSyncCitations for 20 references, and latexCompile for PDF; exportMermaid diagrams multimodality algorithm.
Use Cases
"Extract intussusception sensitivity rates from 10 papers and meta-analyze with Python."
Research Agent → searchPapers → Analysis Agent → readPaperContent (Marsicovetere 2016 et al.) → runPythonAnalysis (pandas forest plot) → researcher gets CSV of pooled 92% CT sensitivity.
"Write LaTeX review on adult intussusception imaging citing top 15 papers."
Synthesis Agent → gap detection → Writing Agent → latexEditText (intro) → latexSyncCitations (Marinis 2009 et al.) → latexCompile → researcher gets camera-ready PDF with target sign figure.
"Find code for intussusception imaging analysis from recent papers."
Research Agent → paperExtractUrls (Pennazio 2022) → paperFindGithubRepo → githubRepoInspect → researcher gets Python scripts for capsule endoscopy feature extraction.
Automated Workflows
Deep Research workflow scans 50+ intussusception papers via searchPapers → citationGraph → structured report on imaging accuracy evolution (2003-2022). DeepScan's 7-steps verify CT superiority claims with CoVe checkpoints against Wang et al. (2009). Theorizer generates hypotheses on AI ultrasound for lead point detection from Marinis et al. (2009) patterns.
Frequently Asked Questions
What defines intussusception in imaging?
Telescoping of proximal bowel into distal segment, appearing as target/sausage sign on CT/ultrasound (Marinis et al., 2009).
What are main diagnostic methods?
Ultrasound first-line in pediatrics; CT most accurate overall, especially adults for lead points (Wang et al., 2009; Marsicovetere et al., 2016).
What are key papers?
Marinis et al. (2009, 811 citations) reviews adults; Wang et al. (2009, 278 citations) validates CT; Yalamarthi and Smith (2005, 240 citations) covers cases.
What open problems exist?
Standardizing transient vs pathologic criteria; improving ultrasound lead point detection; adult preoperative diagnosis speed (Yakan et al., 2009).
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