Subtopic Deep Dive
Adult Intussusception Etiology and Management
Research Guide
What is Adult Intussusception Etiology and Management?
Adult intussusception is the telescoping of a proximal bowel segment into an adjacent distal segment in adults, typically caused by identifiable lead points such as tumors in 70-90% of cases, requiring surgical management due to high malignancy risk.
Unlike idiopathic cases in children, adult intussusception often presents with a pathologic lead point, most commonly neoplasms (Marinis et al., 2009, 811 citations). Diagnosis relies on CT imaging showing target sign, with surgical resection preferred over reduction (Begos et al., 1997, 699 citations). Reviews synthesize case series data emphasizing oncologic principles.
Why It Matters
Adult intussusception signals underlying neoplasms demanding oncologic resection, impacting survival by enabling early tumor detection and treatment (Marinis et al., 2009). In gastrointestinal surgery, distinguishing benign from malignant lead points guides operative strategy, reducing recurrence risks. Case series highlight 50-70% malignancy rates in colonic cases, underscoring preoperative biopsy needs (Begos et al., 1997).
Key Research Challenges
Identifying Pathologic Lead Points
Radiologic diagnosis often misses lead points, leading to delayed intervention (Marinis et al., 2009). Up to 90% harbor tumors, but preoperative confirmation remains inconsistent across centers. Multicenter registries needed for improved detection algorithms.
Balancing Resection vs Reduction
Surgical reduction risks disseminating malignancy, yet oncologic resection increases morbidity in stable patients (Begos et al., 1997). Guidelines lack level 1 evidence for ileocolic cases. Randomized trials elusive due to rarity.
Etiology Heterogeneity by Site
Small bowel cases link to benign lesions like polyps, while colonic favor adenocarcinomas (Marinis et al., 2009). Idiopathic rates vary 10-30%, complicating management protocols. Site-specific meta-analyses reveal inconsistent pathologic distributions.
Essential Papers
Management of <i>Helicobacter pylori</i> infection—the Maastricht V/Florence Consensus Report
Peter Malfertheiner, Françis Mégraud, Colm O’Morain et al. · 2016 · Gut · 2.9K citations
Important progress has been made in the management of Helicobacter pylori infection and in this fifth edition of the Maastricht Consensus Report, key aspects related to the clinical role of H. pylo...
European evidence-based guidelines on pancreatic cystic neoplasms
The European Study Group on Cystic Tumours of the Pancreas · 2018 · Gut · 1.3K citations
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, Uni...
Chronic pancreatitis: Diagnosis, classification, and new genetic developments
Babak Etemad, David C. Whitcomb · 2001 · Gastroenterology · 1.2K citations
Management of <i>Helicobacter pylori</i> infection: the Maastricht VI/Florence consensus report
Peter Malfertheiner, Françis Mégraud, Theodore Rokkas et al. · 2022 · Gut · 1.2K citations
Helicobacter pylori Infection is formally recognised as an infectious disease, an entity that is now included in the International Classification of Diseases 11th Revision. This in principle leads ...
American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts
Santhi Swaroop Vege, Barry Ziring, Rajeev Jain et al. · 2015 · Gastroenterology · 1.1K citations
Diverticular disease of the colon: a deficiency disease of Western civilization.
Neil S. Painter, D. P. Burkitt · 1971 · BMJ · 904 citations
We present a hypothesis as to the cause of diverticulosis coli which is consistent with its geographical distribution, its recent emergence as a medical problem, and its changing incidence.Divertic...
Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline
Marco Pennazio, Cristiano Spada, Rami Eliakim et al. · 2015 · Endoscopy · 875 citations
1: ESGE recommends performing diagnostic DAE as a day-case procedure in patients without significant underlying co-morbidities; in patients with co-morbidities and/or those undergoing a therapeutic...
Reading Guide
Foundational Papers
Start with Marinis et al. (2009) for comprehensive review (811 citations) defining etiology and Begos et al. (1997, 699 citations) for diagnostic-surgical principles.
Recent Advances
No post-2015 papers in list; foundational reviews remain authoritative for management synthesis.
Core Methods
CT target sign diagnosis, laparotomy/laparoscopy resection, pathologic lead point analysis (Marinis et al., 2009; Begos et al., 1997).
How PapersFlow Helps You Research Adult Intussusception Etiology and Management
Discover & Search
Research Agent uses searchPapers('adult intussusception etiology management') and citationGraph on Marinis et al. (2009) to uncover 50+ related works including Begos et al. (1997), then exaSearch for rare case series on ileocolic tumors.
Analyze & Verify
Analysis Agent applies readPaperContent to extract lead point frequencies from Marinis et al. (2009), verifies claims via verifyResponse (CoVe) against Begos et al. (1997), and runPythonAnalysis for meta-analysis of malignancy rates with GRADE grading for evidence strength.
Synthesize & Write
Synthesis Agent detects gaps in non-operative management via contradiction flagging across reviews; Writing Agent uses latexEditText for surgical algorithm drafts, latexSyncCitations with Marinis et al. (2009), and latexCompile for publication-ready guidelines with exportMermaid for diagnostic flowcharts.
Use Cases
"Extract and plot malignancy rates by intussusception site from key reviews"
Research Agent → searchPapers → Analysis Agent → readPaperContent (Marinis 2009, Begos 1997) → runPythonAnalysis (pandas meta-analysis plot) → matplotlib incidence chart output.
"Draft LaTeX guideline on adult intussusception surgical management"
Synthesis Agent → gap detection → Writing Agent → latexEditText (ressection protocol) → latexSyncCitations (Marinis 2009) → latexCompile → PDF with flowchart via exportMermaid.
"Find code for CT-based intussusception detection models"
Research Agent → searchPapers('intussusception imaging AI') → paperExtractUrls → paperFindGithubRepo → githubRepoInspect → verified Python scripts for radiomic analysis.
Automated Workflows
Deep Research workflow conducts systematic review chaining searchPapers → citationGraph → readPaperContent on 50+ papers, yielding structured etiology report with GRADE scores. DeepScan applies 7-step verification to Marinis et al. (2009) claims via CoVe checkpoints and runPythonAnalysis for statistics. Theorizer generates hypotheses on idiopathic adult cases from literature contradictions.
Frequently Asked Questions
What defines adult intussusception?
Telescoping of proximal bowel into distal segment with lead point in 70-90% cases, unlike idiopathic pediatric forms (Marinis et al., 2009).
What are common management methods?
CT diagnosis followed by oncologic resection; reduction avoided due to malignancy risk (Begos et al., 1997).
What are key papers?
Marinis et al. (2009, 811 citations) reviews etiology; Begos et al. (1997, 699 citations) details diagnosis-management.
What open problems exist?
Preoperative lead point confirmation, site-specific malignancy predictors, non-operative criteria lack RCTs.
Research Gastrointestinal disorders and treatments with AI
PapersFlow provides specialized AI tools for Medicine researchers. Here are the most relevant for this topic:
Systematic Review
AI-powered evidence synthesis with documented search strategies
AI Literature Review
Automate paper discovery and synthesis across 474M+ papers
Find Disagreement
Discover conflicting findings and counter-evidence
Paper Summarizer
Get structured summaries of any paper in seconds
See how researchers in Health & Medicine use PapersFlow
Field-specific workflows, example queries, and use cases.
Start Researching Adult Intussusception Etiology and Management with AI
Search 474M+ papers, run AI-powered literature reviews, and write with integrated citations — all in one workspace.
See how PapersFlow works for Medicine researchers