Subtopic Deep Dive
Core-Shell Electrospun Nanofibers for Biomedical Applications
Research Guide
What is Core-Shell Electrospun Nanofibers for Biomedical Applications?
Core-shell electrospun nanofibers are produced via coaxial electrospinning, featuring distinct core and shell polymer phases for controlled delivery of biologics and drugs in biomedical applications.
Coaxial electrospinning enables encapsulation of sensitive therapeutics in the core while the shell provides mechanical stability and biocompatibility. Research demonstrates dual-drug release profiles for tissue regeneration and wound healing. Over 500 papers explore these structures, building on foundational reviews like Persano et al. (2013) with 905 citations.
Why It Matters
Core-shell nanofibers enable sustained growth factor release for bone tissue engineering, as shown in Ji et al. (2010) delivering bioactive scaffolds. They support dual-drug delivery systems for complex wound therapies, extending Graça et al. (2020) hyaluronic acid dressings. Ramakrishna et al. (2013) highlight their role in scalable drug delivery, impacting clinical translation in regenerative medicine.
Key Research Challenges
Core-Shell Jet Stability
Maintaining coaxial jet integrity during electrospinning remains difficult due to mismatched viscosities between core and shell solutions. Persano et al. (2013) note processing variables affect fiber morphology. Pillay et al. (2013) identify flow rate imbalances as key disruptors.
Biologic Encapsulation Stability
Preserving activity of encapsulated proteins or genes challenges core-shell designs under electrospinning voltages. Ji et al. (2010) address growth factor denaturation in bioactive scaffolds. Chakraborty et al. (2009) discuss electrohydrodynamic stresses on sensitive payloads.
Controlled Dual-Drug Release
Achieving independent release kinetics from core and shell phases requires precise polymer selection. Ramakrishna et al. (2013) review diffusion barriers in EHD nanofibers. Jang et al. (2009) highlight mismatched degradation rates in bone scaffolds.
Essential Papers
Industrial Upscaling of Electrospinning and Applications of Polymer Nanofibers: A Review
Luana Persano, Andrea Camposeo, Ç. Tekmen et al. · 2013 · Macromolecular Materials and Engineering · 905 citations
Abstract Electrospun nanofibers are extensively studied and their potential applications are largely demonstrated. Today, electrospinning equipment and technological solutions, and electrospun mate...
Hyaluronic acid—Based wound dressings: A review
Mariana F.P. Graça, Sónia P. Miguel, Cátia S.D. Cabral et al. · 2020 · Carbohydrate Polymers · 759 citations
A Review of the Effect of Processing Variables on the Fabrication of Electrospun Nanofibers for Drug Delivery Applications
Viness Pillay, Clare Dott, Yahya E. Choonara et al. · 2013 · Journal of Nanomaterials · 669 citations
Electrospinning is a fast emerging technique for producing ultrafine fibers by utilizing electrostatic repulsive forces. The technique has gathered much attention due to the emergence of nanotechno...
Advances in drug delivery via electrospun and electrosprayed nanomaterials
Seeram Ramakrishna, Maedeh Zamani, Molamma P Prabhakaran · 2013 · International Journal of Nanomedicine · 585 citations
Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through...
Electrohydrodynamics: A facile technique to fabricate drug delivery systems
Syandan Chakraborty, I‐Chien Liao, Andrew F. Adler et al. · 2009 · Advanced Drug Delivery Reviews · 538 citations
Electrospun materials as potential platforms for bone tissue engineering
Jun‐Hyeog Jang, Óscar Castaño, Hae‐Won Kim · 2009 · Advanced Drug Delivery Reviews · 491 citations
Biomedical Applications of Biodegradable Polyesters
Iman Manavitehrani, Ali Fathi, Hesham Badr et al. · 2016 · Polymers · 487 citations
The focus in the field of biomedical engineering has shifted in recent years to biodegradable polymers and, in particular, polyesters. Dozens of polyester-based medical devices are commercially ava...
Reading Guide
Foundational Papers
Start with Persano et al. (2013, 905 citations) for electrospinning upscaling basics, then Pillay et al. (2013, 669 citations) on processing for core-shell drug delivery, and Chakraborty et al. (2009, 538 citations) on EHD fabrication techniques.
Recent Advances
Study Graça et al. (2020, 759 citations) for wound dressing integrations and Barhoum et al. (2019, 441 citations) for emerging nanofiber applications in biomedicine.
Core Methods
Core methods include coaxial electrospinning with viscosity-matched solutions (Pillay et al. 2013), core encapsulation for biologics (Ji et al. 2010), and shell barrier design for release control (Ramakrishna et al. 2013).
How PapersFlow Helps You Research Core-Shell Electrospun Nanofibers for Biomedical Applications
Discover & Search
Research Agent uses searchPapers('core-shell electrospun nanofibers biomedical') to retrieve 200+ papers, then citationGraph on Persano et al. (2013) reveals 905-citation hub connecting coaxial spinning reviews to drug delivery. findSimilarPapers expands to core-shell specifics from Ramakrishna et al. (2013); exaSearch uncovers niche biomedical applications.
Analyze & Verify
Analysis Agent applies readPaperContent to Pillay et al. (2013) extracting coaxial parameters, then runPythonAnalysis on release kinetics data with NumPy for diffusion modeling verification. verifyResponse (CoVe) cross-checks claims against Ji et al. (2010); GRADE grading scores evidence strength for growth factor stability in scaffolds.
Synthesize & Write
Synthesis Agent detects gaps in dual-drug release via contradiction flagging across Chakraborty et al. (2009) and Ramakrishna et al. (2013). Writing Agent uses latexEditText for manuscript sections, latexSyncCitations integrating 50+ references, and latexCompile for camera-ready output; exportMermaid diagrams core-shell architectures.
Use Cases
"Model core-shell drug release kinetics from electrospinning papers"
Research Agent → searchPapers → Analysis Agent → runPythonAnalysis (pandas fits diffusion models from Pillay et al. 2013 data) → matplotlib plots biphasic release curves.
"Write review section on core-shell nanofibers for bone scaffolds"
Synthesis Agent → gap detection → Writing Agent → latexEditText(draft) → latexSyncCitations(Ji et al. 2010, Jang et al. 2009) → latexCompile → PDF with diagrams.
"Find code for simulating coaxial electrospinning jets"
Research Agent → paperExtractUrls(Garg et al. 2011) → paperFindGithubRepo → githubRepoInspect → runPythonAnalysis verifies jet stability simulation code.
Automated Workflows
Deep Research workflow scans 50+ core-shell papers via searchPapers → citationGraph → structured report on biomedical trends from Persano et al. (2013). DeepScan's 7-step chain analyzes Ji et al. (2010) with CoVe checkpoints and Python release modeling. Theorizer generates hypotheses on shell thickness optimizing dual-release from Ramakrishna et al. (2013).
Frequently Asked Questions
What defines core-shell electrospun nanofibers?
They feature a core polymer phase encapsulating therapeutics surrounded by a protective shell, produced by coaxial electrospinning for biomedical uses like drug delivery.
What are main fabrication methods?
Coaxial electrospinning uses dual nozzles with core-shell solutions; key variables include flow rates and voltages per Pillay et al. (2013). Persano et al. (2013) detail upscaling for stability.
What are key papers?
Persano et al. (2013, 905 citations) reviews upscaling; Ramakrishna et al. (2013, 585 citations) covers drug delivery; Ji et al. (2010, 403 citations) focuses on growth factor scaffolds.
What open problems exist?
Challenges include jet stability, biologic preservation, and independent dual-release control, as noted in Chakraborty et al. (2009) and Jang et al. (2009).
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