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Congenital Diaphragmatic Hernia Studies
Research Guide
What is Congenital Diaphragmatic Hernia Studies?
Congenital Diaphragmatic Hernia Studies is a field of medical research focused on the diagnosis, prenatal prediction of survival, fetal surgery, lung volume assessment, genetic factors such as DICER1 mutations, pulmonary hypoplasia, and treatment outcomes including extracorporeal membrane oxygenation and thoracoscopic repair for congenital diaphragmatic hernia.
The field encompasses 79,223 published works on congenital diaphragmatic hernia, addressing prenatal diagnosis, fetal lung development, and long-term patient follow-up. Research examines pulmonary hypoplasia and interventions like extracorporeal membrane oxygenation to improve neonatal survival. Growth rate over the past 5 years is not available in the provided data.
Topic Hierarchy
Research Sub-Topics
Prenatal Prediction of Congenital Diaphragmatic Hernia Survival
This sub-topic examines fetal MRI-based lung volume measurements, observed-to-expected lung-head ratio, and Doppler assessments to predict postnatal survival. Researchers develop prognostic models incorporating liver position and gestational age.
Fetal Surgery for Congenital Diaphragmatic Hernia
This sub-topic covers fetoscopic endoluminal tracheal occlusion (FETO) techniques, balloon placement protocols, and reversal procedures to promote lung growth. Researchers conduct randomized trials assessing perinatal outcomes versus postnatal management.
Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia
This sub-topic investigates the pathogenesis of lung underdevelopment, alveolar simplification, and pulmonary vascular bed abnormalities in CDH. Researchers study stem cell therapies, growth factor signaling, and postnatal lung growth trajectories.
Extracorporeal Membrane Oxygenation in CDH
This sub-topic evaluates ECMO candidacy criteria, veno-venous vs. veno-arterial modes, and weaning protocols for CDH neonates with persistent pulmonary hypertension. Researchers analyze multicenter registry data for survival predictors and complications.
Thoracoscopic Repair of Congenital Diaphragmatic Hernia
This sub-topic compares minimally invasive thoracoscopic techniques versus open repair regarding recurrence rates, operative time, and neurodevelopmental outcomes. Researchers address learning curves, patch materials, and hernia sac management.
Why It Matters
Studies on congenital diaphragmatic hernia guide clinical management by predicting survival prenatally and evaluating fetal surgery efficacy, directly impacting neonatal care in surgical and intensive care units. For instance, assessments of lung volume and pulmonary hypoplasia inform decisions on extracorporeal membrane oxygenation use, a treatment associated with variable outcomes in affected infants. Research on DICER1 mutations links the condition to pleuropulmonary blastoma, enabling targeted genetic screening and long-term follow-up protocols to reduce morbidity in pediatric patients.
Reading Guide
Where to Start
"Bronchopulmonary Dysplasia" by Jobe and Bancalari (2001) is the starting paper because it provides foundational understanding of chronic lung disease in neonates, directly relevant to pulmonary hypoplasia in congenital diaphragmatic hernia.
Key Papers Explained
"Bronchopulmonary Dysplasia" by Jobe and Bancalari (2001) establishes neonatal lung injury mechanisms, which "Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth" by Roberts et al. (2017) builds on by showing corticosteroid benefits for lung maturation. "A CONTROLLED TRIAL OF ANTEPARTUM GLUCOCORTICOID TREATMENT FOR PREVENTION OF THE RESPIRATORY DISTRESS SYNDROME IN PREMATURE INFANTS" by Liggins and Howie (1972) provides the original trial evidence for glucocorticoids, while "Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network" by Stoll et al. (2010) connects these to gestational age-specific morbidity data applicable to hernia outcomes.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Current research emphasizes prenatal survival prediction, fetal surgery optimization, and DICER1 mutation impacts, with focus on long-term follow-up after extracorporeal membrane oxygenation and thoracoscopic repair; no recent preprints or news available.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Bronchopulmonary Dysplasia | 2001 | American Journal of Re... | 4.7K | ✕ |
| 2 | ACUTE RESPIRATORY DISTRESS IN ADULTS | 1967 | The Lancet | 4.2K | ✕ |
| 3 | A Perivascular Origin for Mesenchymal Stem Cells in Multiple H... | 2008 | Cell stem cell | 3.9K | ✓ |
| 4 | Pulmonary Disease Following Respirator Therapy of Hyaline-Memb... | 1967 | New England Journal of... | 3.0K | ✕ |
| 5 | Mice carrying null mutations of the genes encoding insulin-lik... | 1993 | Cell | 2.9K | ✕ |
| 6 | Surgical repair of tricuspid atresia | 1971 | Thorax | 2.8K | ✓ |
| 7 | Antenatal corticosteroids for accelerating fetal lung maturati... | 2017 | Cochrane Database of S... | 2.8K | ✓ |
| 8 | Global burden of acute lower respiratory infections due to res... | 2010 | The Lancet | 2.8K | ✓ |
| 9 | Neonatal Outcomes of Extremely Preterm Infants From the NICHD ... | 2010 | PEDIATRICS | 2.7K | ✓ |
| 10 | A CONTROLLED TRIAL OF ANTEPARTUM GLUCOCORTICOID TREATMENT FOR ... | 1972 | PEDIATRICS | 2.5K | ✕ |
Frequently Asked Questions
What is the scope of Congenital Diaphragmatic Hernia Studies?
Congenital Diaphragmatic Hernia Studies covers diagnosis and management of congenital diaphragmatic hernia, including prenatal survival prediction, fetal surgery, lung volume assessment, DICER1 mutations, pulmonary hypoplasia, extracorporeal membrane oxygenation, thoracoscopic repair, fetal lung development, pleuropulmonary blastoma, and long-term patient follow-up. The field includes 79,223 works. These topics address key challenges in neonatal surgery and respiratory care.
How do antenatal corticosteroids relate to Congenital Diaphragmatic Hernia Studies?
"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth" by Roberts et al. (2017) shows that a single course reduces perinatal death, neonatal death, and respiratory distress syndrome risk. This supports fetal lung maturation in preterm infants at risk of complications like pulmonary hypoplasia seen in congenital diaphragmatic hernia. The review confirms benefits for women at preterm birth risk.
What role does bronchopulmonary dysplasia play in Congenital Diaphragmatic Hernia Studies?
"Bronchopulmonary Dysplasia" by Jobe and Bancalari (2001) examines chronic lung disease in preterm infants, relevant to pulmonary hypoplasia outcomes in congenital diaphragmatic hernia. The paper, with 4654 citations, details pathophysiology following respiratory support. It informs management strategies post-repair or extracorporeal membrane oxygenation.
How are neonatal respiratory outcomes studied in this field?
"Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network" by Stoll et al. (2010) reports morbidity and mortality by gestational age in very low birth weight infants. Data highlight respiratory distress risks paralleling congenital diaphragmatic hernia challenges. Findings guide prenatal and postnatal interventions.
What is the impact of glucocorticoid treatment in fetal lung development?
"A CONTROLLED TRIAL OF ANTEPARTUM GLUCOCORTICOID TREATMENT FOR PREVENTION OF THE RESPIRATORY DISTRESS SYNDROME IN PREMATURE INFANTS" by Liggins and Howie (1972) demonstrates betamethasone reduces respiratory distress syndrome incidence in infants from mothers treated before 37 weeks gestation. Two hundred fifty-three of 282 mothers completed the trial. This supports accelerating fetal lung maturation relevant to hernia-related hypoplasia.
What are key treatments in Congenital Diaphragmatic Hernia management?
Treatments include fetal surgery, extracorporeal membrane oxygenation, and thoracoscopic repair. Studies assess pulmonary hypoplasia and lung volume to predict outcomes. Long-term follow-up addresses complications like pleuropulmonary blastoma linked to DICER1 mutations.
Open Research Questions
- ? How can prenatal imaging accurately predict lung volume and survival in fetuses with congenital diaphragmatic hernia?
- ? What is the precise role of DICER1 mutations in causing pulmonary hypoplasia and pleuropulmonary blastoma in congenital diaphragmatic hernia patients?
- ? Which patient subgroups benefit most from fetal surgery versus postnatal extracorporeal membrane oxygenation?
- ? How do long-term neurodevelopmental outcomes vary after thoracoscopic repair in congenital diaphragmatic hernia cases?
- ? What mechanisms underlie persistent pulmonary hypertension despite interventions in congenital diaphragmatic hernia?
Recent Trends
The field maintains 79,223 works with no specified 5-year growth rate; highly cited papers like "Bronchopulmonary Dysplasia" by Jobe and Bancalari (2001, 4654 citations) and "Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth" by Roberts et al. (2017, 2757 citations) underscore ongoing relevance of lung protection strategies to congenital diaphragmatic hernia management.
No recent preprints or news reported in the last 6-12 months.
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