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Apelin-related biomedical research
Research Guide
What is Apelin-related biomedical research?
Apelin-related biomedical research is the study of apelin, a novel adipokine, and its receptor APJ in physiological processes including cardiovascular regulation, angiogenesis, obesity, diabetes, and neuroprotection, along with their molecular properties, tissue distribution, signaling pathways, therapeutic potential, and pathophysiological implications.
The field encompasses 16,356 published works on the apelin/APJ system. Research examines its roles in cardiovascular regulation, angiogenesis, obesity, diabetes, hypertension, and neuroprotection. Key aspects include molecular properties, tissue distribution, and signaling pathways of this G protein-coupled receptor system.
Topic Hierarchy
Research Sub-Topics
Apelin in Cardiovascular Regulation
Researchers investigate the role of apelin and APJ receptor in blood pressure control, vascular tone modulation, and cardiac contractility through G-protein coupled signaling pathways. Studies focus on apelin's hypotensive effects and its potential in treating hypertension and heart failure.
Apelin and Angiogenesis
This area examines apelin's promotion of endothelial cell proliferation, migration, and new vessel formation via APJ-mediated pathways in physiological and pathological contexts. Research explores its interactions with VEGF and roles in ischemia and tumor vascularization.
Apelin in Metabolic Disorders
Studies analyze apelin's effects on insulin sensitivity, glucose homeostasis, and adipogenesis in obesity and type 2 diabetes models. Researchers elucidate APJ signaling in adipose tissue and its therapeutic modulation of metabolic syndrome.
Apelin Neuroprotection
Research explores apelin's protective effects against neuronal injury, ischemia, and neurodegeneration through APJ receptor activation in the brain. It covers apelin's anti-apoptotic signaling and roles in stroke and Alzheimer's disease models.
Apelin APJ Signaling Pathways
This sub-topic dissects the molecular mechanisms of APJ activation by apelin, including PI3K/Akt, MAPK/ERK, and beta-arrestin pathways in various cell types. Researchers study receptor desensitization, biased agonism, and downstream effectors.
Why It Matters
Apelin-related biomedical research addresses physiological processes with therapeutic potential in cardiovascular regulation, angiogenesis, obesity, and diabetes. "Mechanisms of angiogenesis and arteriogenesis" by Peter Carmeliet (2000) details vascular growth mechanisms relevant to apelin's angiogenic effects, cited 4116 times. "Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome" by Takashi Kadowaki (2006) links adipokines like apelin to insulin sensitization and metabolic disorders, with 2792 citations. These connections highlight applications in treating hypertension and diabetes through apelin/APJ modulation.
Reading Guide
Where to Start
"Mechanisms of angiogenesis and arteriogenesis" by Peter Carmeliet (2000) is the starting point for beginners, as its 4116 citations provide foundational understanding of vascular processes central to apelin's angiogenic roles.
Key Papers Explained
"Mechanisms of angiogenesis and arteriogenesis" by Peter Carmeliet (2000) establishes vascular mechanisms that apelin/APJ influences. "Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome" by Takashi Kadowaki (2006) connects adipokine signaling to metabolic diseases overlapping with apelin research. "Role of Brain Insulin Receptor in Control of Body Weight and Reproduction" by Jens C. Brüning et al. (2000) extends to CNS insulin pathways relevant to apelin's neuroprotective and metabolic effects. "Endothelial cells in physiology and in the pathophysiology of vascular disorders" by Douglas B. Cines et al. (1998) builds on endothelial functions tied to apelin's cardiovascular regulation.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
Research centers on apelin/APJ in cardiovascular, metabolic, and neuroprotective contexts from the 16,356 papers. No recent preprints or news coverage in the last 12 months indicates steady focus on established signaling pathways and therapeutic potential without new breakthroughs.
Papers at a Glance
Frequently Asked Questions
What physiological processes does apelin research target?
Apelin research targets cardiovascular regulation, angiogenesis, obesity, diabetes, hypertension, and neuroprotection. The apelin/APJ system influences these via adipokine signaling. This covers molecular properties, tissue distribution, and pathophysiological implications.
How many papers exist on apelin-related biomedical research?
There are 16,356 published works in this field. Growth rate over the past 5 years is not available. The corpus focuses on apelin and APJ receptor functions.
What is the role of apelin as an adipokine?
Apelin is a novel adipokine acting through the APJ receptor, a G protein-coupled receptor. It participates in metabolic regulation including obesity and diabetes. Research explores its signaling pathways and therapeutic potential.
Which highly cited paper relates to angiogenesis in apelin research?
"Mechanisms of angiogenesis and arteriogenesis" by Peter Carmeliet (2000) elucidates vascular growth processes pertinent to apelin's angiogenic actions. It has 4116 citations. This informs apelin/APJ roles in vascular physiology.
What metabolic aspects does apelin research cover?
Apelin research covers obesity, diabetes, and insulin resistance via the adipokine APJ system. "Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome" by Takashi Kadowaki (2006) provides context with 2792 citations. Therapeutic implications arise from these pathways.
What is the current state of apelin-related biomedical research?
The field includes 16,356 papers with no recent preprints or news in the last 12 months. Focus remains on established roles in cardiovascular and metabolic processes. No growth rate data over 5 years is available.
Open Research Questions
- ? How does the apelin/APJ system specifically interact with insulin signaling pathways in the central nervous system to regulate body weight and reproduction?
- ? What are the precise molecular mechanisms by which apelin influences stimulus-transcription coupling involving proto-oncogenes like fos and jun in neuroprotection?
- ? In what ways does apelin modulate endothelial cell functions in vascular pathophysiology beyond basic permeability maintenance?
- ? How does the apelin system contribute to neurocircuitry controlling the hypothalamo-pituitary-adrenocortical axis under stress?
- ? What signaling cascades link apelin to growth factor responses and inflammation in exercise-induced brain health?
Recent Trends
The field maintains 16,356 papers with no 5-year growth rate available.
No preprints from the last 6 months or news in the last 12 months reported.
Citation leaders like "Mechanisms of angiogenesis and arteriogenesis" by Peter Carmeliet (2000, 4116 citations) and "Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome" by Takashi Kadowaki (2006, 2792 citations) continue to anchor research on apelin's vascular and metabolic roles.
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