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Antioxidants, Aging, Portulaca oleracea
Research Guide
What is Antioxidants, Aging, Portulaca oleracea?
Antioxidants, Aging, Portulaca oleracea refers to research examining the neuroprotective effects of purslane (Portulaca oleracea) and other antioxidants against D-galactose-induced oxidative stress, neurodegeneration, memory impairment, and accelerated aging in animal models.
This field investigates chronic D-galactose exposure as a model for aging, which induces memory loss, neurodegeneration, and oxidative damage in mice. Portulaca oleracea demonstrates protective effects against these D-galactose-induced deficits. The topic encompasses 20,659 works with a recurring focus on natural antioxidants like R-α-lipoic acid.
Topic Hierarchy
Research Sub-Topics
D-Galactose Induced Aging Model
The D-galactose mouse/rat model recapitulates aging phenotypes including cognitive decline, oxidative damage, and neurodegeneration via chronic injection or administration. Researchers standardize protocols, characterize biomarkers, and validate model reliability across strains.
Portulaca oleracea Neuroprotective Effects
Purslane extracts ameliorate D-galactose induced memory impairment, oxidative stress, and neuroinflammation through antioxidant betacyanins and omega-3 fatty acids. Studies elucidate molecular mechanisms, optimal dosages, and behavioral outcomes.
Oxidative Stress in D-Galactose Aging
D-galactose metabolism generates ROS via aldose reductase pathway, elevating brain/liver oxidative markers and depleting antioxidants. Research quantifies MDA, protein carbonyls, and antioxidant enzyme alterations across tissues.
Neuroprotective Effects of R-Alpha-Lipoic Acid
R-lipoic acid prevents D-gal-induced spatial memory deficits, cholinergic dysfunction, and amyloid pathology through mitochondrial protection and antioxidant recycling. Dose-response and mechanistic studies identify optimal therapeutic windows.
Cognitive Impairment in D-Galactose Model
Morris water maze and novel object recognition deficits characterize D-galactose cognitive decline linked to hippocampal neurogenesis suppression and synaptic protein loss. Interventions restore BDNF signaling and memory performance.
Why It Matters
Research in this area identifies natural compounds that counteract D-galactose-induced aging effects in animal models, offering potential interventions for oxidative stress-related neurodegeneration. Xu Cui et al. (2006) in "Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid" showed that R-α-lipoic acid at 100 mg/kg/day restored cognitive function and reduced oxidative markers like MDA in mouse brains after 45 days of D-galactose treatment. Similarly, "<i>Portulaca oleracea</i>L.: A Review of Phytochemistry and Pharmacological Effects" by Yanxi Zhou et al. (2015) details purslane's antioxidants, including flavonoids and polysaccharides, which ameliorate inflammation and cognitive dysfunction, supporting applications in dietary neuroprotective strategies.
Reading Guide
Where to Start
"d-Galactose-induced accelerated aging model: an overview" by Khairunnuur Fairuz Azman and Rahimah Zakaria (2019), as it provides a foundational summary of the D-galactose model central to studies on antioxidants and Portulaca oleracea.
Key Papers Explained
Xu Cui et al. (2006) in "Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid" establishes the mouse model and R-α-lipoic acid's benefits, building on Shih-Ching Ho et al. (2003) in "Establishment of the mimetic aging effect in mice caused by D-galactose" which defined the D-galactose protocol. Yanxi Zhou et al. (2015) in "<i>Portulaca oleracea</i>L.: A Review of Phytochemistry and Pharmacological Effects" connects by reviewing purslane's antioxidants applicable to this model. Khairunnuur Fairuz Azman and Rahimah Zakaria (2019) in "d-Galactose-induced accelerated aging model: an overview" synthesizes these for broader context.
Paper Timeline
Most-cited paper highlighted in red. Papers ordered chronologically.
Advanced Directions
No recent preprints or news coverage from the last 12 months or 6 months indicate steady progress without new public developments. Focus remains on established D-galactose models and natural antioxidants like Portulaca oleracea.
Papers at a Glance
| # | Paper | Year | Venue | Citations | Open Access |
|---|---|---|---|---|---|
| 1 | Crassulacean Acid Metabolism | 1960 | Annual Review of Plant... | 1.0K | ✕ |
| 2 | Millet based Nutritious Powder for the Geriatric Population | 2024 | International Journal ... | 959 | ✓ |
| 3 | d-Galactose-induced accelerated aging model: an overview | 2019 | Biogerontology | 460 | ✕ |
| 4 | ABSENCE AND PRESENCE OF FLUID FROM NORMAL AND INFLAMED GINGIVAE. | 1996 | PubMed | 406 | ✕ |
| 5 | Chronic systemic D‐galactose exposure induces memory loss, neu... | 2006 | Journal of Neuroscienc... | 398 | ✕ |
| 6 | Fasting and cancer treatment in humans: A case series report | 2009 | Aging | 383 | ✓ |
| 7 | <i>Portulaca oleracea</i>L.: A Review of Phytochemistry and Ph... | 2015 | BioMed Research Intern... | 367 | ✓ |
| 8 | In vitro and in vivo antioxidant activity of aqueous extract f... | 2007 | Food Chemistry | 352 | ✕ |
| 9 | Praktikum der Zell- und Gewebephysiologie der Pflanze | 1949 | — | 350 | ✕ |
| 10 | Establishment of the mimetic aging effect in mice caused by D-... | 2003 | Biogerontology | 349 | ✕ |
Frequently Asked Questions
What is the D-galactose aging model?
Chronic systemic D-galactose exposure accelerates senescence in mice, rats, and Drosophila, inducing memory loss, neurodegeneration, and oxidative damage. Khairunnuur Fairuz Azman and Rahimah Zakaria (2019) in "d-Galactose-induced accelerated aging model: an overview" describe it as a tool to study aging mechanisms. Shih-Ching Ho et al. (2003) in "Establishment of the mimetic aging effect in mice caused by D-galactose" established doses of 100 mg/kg/day subcutaneously for 6 weeks to mimic aging in mice.
How does Portulaca oleracea protect against aging?
Portulaca oleracea, or purslane, contains phytochemicals like flavonoids and polysaccharides with antioxidant and anti-inflammatory properties. Yanxi Zhou et al. (2015) in "<i>Portulaca oleracea</i>L.: A Review of Phytochemistry and Pharmacological Effects" report its role in reducing oxidative stress and cognitive impairment. It ameliorates D-galactose-induced effects through neuroprotective mechanisms.
What protective effects does R-α-lipoic acid show?
R-α-lipoic acid prevents memory loss and neurodegeneration from chronic D-galactose in mice. Xu Cui et al. (2006) in "Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid" found 100 mg/kg/day restored spatial memory in Morris water maze tests. It also lowered brain MDA levels and boosted antioxidant enzymes.
What are key keywords in this research?
Core terms include D-Galactose, Aging, Neurodegeneration, Oxidative Stress, Memory Impairment, Antioxidant, Portulaca Oleracea, Cognitive Dysfunction, Neuroprotective Effects, and Inflammation. These reflect the focus on D-galactose models and natural compound interventions.
How many papers cover this topic?
The field includes 20,659 works. Growth data over 5 years is not available.
Open Research Questions
- ? What specific phytochemicals in Portulaca oleracea mediate protection against D-galactose-induced neurodegeneration?
- ? How does chronic D-galactose exposure mechanistically cause oxidative damage in neuronal cells?
- ? Can Portulaca oleracea extracts fully reverse cognitive impairments in D-galactose mouse models?
- ? What dosage and duration of antioxidants like R-α-lipoic acid optimize neuroprotection?
- ? Do Portulaca oleracea effects extend to non-rodent aging models?
Recent Trends
The field maintains 20,659 works with no specified 5-year growth rate.
Highly cited papers like "<i>Portulaca oleracea</i>L.: A Review of Phytochemistry and Pharmacological Effects" (367 citations, 2015) and "Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid" (398 citations, 2006) continue to anchor research.
No recent preprints or news in the last 6-12 months reported.
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